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[Preprint]. 2024 Jul 14:2024.07.12.24310348.
doi: 10.1101/2024.07.12.24310348.

Metformin reduces the risk of poor treatment outcomes among individuals with rifampicin-resistant tuberculosis and type-2 diabetes mellitus

Argita D Salindri  1   2 , Mariam Gujabidze  3 , Maia Kipiani  3   4   5 , Nino Lomtadze  3   4 , Nestani Tukvadze  3   6 , Zaza Avaliani  3   7 , Henry M Blumberg  8   9   10 , Hardy Kornfeld  11 , Russell R Kempker  10 , Matthew J Magee  8   9
Affiliations

Metformin reduces the risk of poor treatment outcomes among individuals with rifampicin-resistant tuberculosis and type-2 diabetes mellitus

Argita D Salindri et al. medRxiv. .

Abstract

We conducted a retrospective cohort study among individuals with rifampicin-resistant tuberculosis and diabetes to determine the association between metformin use and tuberculosis treatment outcomes. We found that individuals with metformin use had a significantly lower risk of poor tuberculosis treatment outcomes (adjusted RR=0.25, 95%CI 0.06 - 0.95) compared to those without.

Keywords: TB treatment outcomes; diabetes; metformin; post-TB mortality; rifampicin-resistant TB; sputum culture conversion.

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Conflict of interest statement

CONFLICT OF INTEREST We have no conflict of interest to declare.

References

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