The Role of Neuro-Immune Interactions in the Pathology and Pathogenesis of Allergic Rhinitis

Abstract

Background: Allergic rhinitis (AR) is a non-infectious inflammatory disease of the nasal mucosa mediated by IgE and involving a variety of immune cells such as mast cells. In previous studies, AR was considered as an isolated disease of the immune system. However, recent studies have found that the nervous system is closely related to the development of AR. Bidirectional communication between the nervous and immune systems plays an important role in AR.

Summary: The nervous system and immune system depend on the anatomical relationship between nerve fibers and immune cells, as well as various neurotransmitters, cytokines, inflammatory mediators, etc. to produce bidirectional connections, which affect the development of AR.

Key messages: This article reviews the impact of neuro-immune interactions in AR on the development of AR, including neuro-immune cell units.

Keywords: Allergic rhinitis; neuro-immune cell units (NICUs); neuron-immue interactions.