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. 2024;11(4):1148-1165.
doi: 10.14283/jpad.2024.79.

Periodontal Disease and Alzheimer's: Insights from a Systematic Literature Network Analysis

A Villar  1 , S Paladini, J Cossatis
Affiliations

Periodontal Disease and Alzheimer's: Insights from a Systematic Literature Network Analysis

A Villar et al. J Prev Alzheimers Dis. 2024.

Abstract

This study investigated the relationship between periodontal disease (PD) and Alzheimer's Disease (AD) through a Systematic Literature Network Analysis (SLNA), combining bibliometric analysis with a Systematic Literature Review (SLR). Analyzing 328 documents from 2000 to 2023, we utilized the Bibliometrix R-package for multiple bibliometric analysis. The SLR primarily centered on the 47 most globally cited papers, highlighting influential research. Our study reveals a positive correlation between Periodontal Disease (PD) and Alzheimer's Disease (AD), grounded in both biological plausibility and a comprehensive review of the literature, yet the exact causal relationship remains a subject of ongoing scientific investigation. We conducted a detailed analysis of the two main pathways by which PD could contribute to brain inflammation: (a) the Inflammatory Cascade, and (b) Microbial Involvement. The results of our SLNA emphasize the importance of oral health in reducing Alzheimer's risk, suggesting that managing periodontal health could be an integral part of Alzheimer's prevention and treatment strategies. The insights from this SLNA pave the way for future research and clinical practices, underscoring the necessity of interdisciplinary methods in both the investigation and treatment of neurodegenerative diseases like Alzheimer's. Furthermore, our study presents a prospective research roadmap to support ongoing advancement in this field.

Keywords: Alzheimer Disease; bibliometrics; neurodegenerative diseases; oral health; periodontal disease.

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Conflict of interest statement

We declare that we have no significant competing financial, professional, or personal interests that might have influenced the performance or presentation of the work described in this manuscript.

Figures

Figure 1
Figure 1
SLNA on Periodontal Disease and Alzheimer's
Figure 2
Figure 2
PRISMA flow diagram summarizing the SLR
Figure 3
Figure 3
Annual Evolution of Scientific Production
Figure 4
Figure 4
Wordcloud
Figure 5
Figure 5
Keywords Co-occurrence Network (KCN)
Figure 6
Figure 6
Most Globally Cited Documents
Figure 7
Figure 7
Periodontal Disease to Alzheimer's: Neuroinflammatory Pathways
See this image and copyright information in PMC

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Uncited reference

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