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. 2024 Mar;17(3):334-340.
doi: 10.25122/jml-2024-0114.

Reproductive outcome after in vitro fertilization in endometriosis - key factors and implications

Elena-Silvia Nadă  1   2 , Ciprian Andrei Coroleucă  1   2 , Cătălin Bogdan Coroleucă  2 , Elvira Brătilă  1   2
Affiliations

Reproductive outcome after in vitro fertilization in endometriosis - key factors and implications

Elena-Silvia Nadă et al. J Med Life. 2024 Mar.

Abstract

Endometriosis is a benign chronic disease with a major impact on a woman's quality of life, mainly due to painful physical symptoms. Endometriosis is also a common cause of infertility caused by low ovarian reserve, distorted pelvic anatomy, and severe local inflammation with a direct negative impact on the quality of oocytes, embryos, and endometrium. We conducted a retrospective study between January 2019 and December 2023, including women with a history of surgery for endometriosis who underwent in vitro fertilization (IVF) to achieve pregnancy. Their reproductive outcome was compared with a group of patients with documented tubal obstruction. The aim of our study was to identify the factors associated with a positive impact on the pregnancy rate, specifically age, anti-Mullerian hormone (AMH), ovarian stimulation protocol, and types of gonadotropins used. We analyzed a group of 175 patients with endometriosis compared with 189 patients with tubal obstruction. The average age was similar between the two groups but with a difference in the average AMH value (1.63 ± 1.09 ng/mL vs. 2.55 ± 1.67 ng/mL). The most utilized ovarian stimulation protocol in both groups was the short gonadotropin-releasing hormone (GnRH) antagonist. The clinical pregnancy rate was 27.2% in the endometriosis group and 54.7% in the tubal obstruction group. Our study revealed that treatment with corifollitropin alfa in the endometriosis group was associated with a higher clinical pregnancy rate. AMH and age proved to be significant independent factors for the reproductive outcome.

Keywords: AMH, anti-Mullerian hormone; BMI, body mass index; ESHRE – European Society of Human Reproduction and Embryology; FSH, follicle-stimulating hormone; GnRH, gonadotropin-releasing hormone; IVF, in vitro fertilization; MRI, magnetic resonance imaging; endometriosis; in vitro fertilization; infertility; ovarian stimulation; pregnancy.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Age distribution of patients across study groups
Figure 2
Figure 2
AMH value distribution in the study groups
Figure 3
Figure 3
Distribution of gonadotropins in patients with endometriosis according to clinical pregnancy rate
Figure 4
Figure 4
Distribution of gonadotropins in patients with tubal obstruction according to clinical pregnancy rate
See this image and copyright information in PMC

References

    1. Rogers PA, Adamson GD, Al-Jefout M, Becker CM, D'Hooghe TM, Dunselman GA, et al. Research priorities for endometriosis. Reprod Sci. 2017;24:202–26. doi: 10.1177/1933719116654991. - DOI - PMC - PubMed
    1. Mehedintu C, Plotogea MN, Ionescu S, Antonovici M. Endometriosis still a challenge. J Med Life. 2014;7:349–57. - PMC - PubMed
    1. Koninckx PR, Fernandes R, Ussia A, Schindler L, Wattiez A, Al-Suwaidi S, et al. Pathogenesis Based Diagnosis and Treatment of Endometriosis. Front Endocrinol (Lausanne) 2021;12:745548. doi: 10.3389/fendo.2021.745548. - DOI - PMC - PubMed
    1. Bulletti C, Coccia ME, Battistoni S, Borini A. Endometriosis and infertility. J Assist Reprod Genet. 2010;27:441–7. doi: 10.1007/s10815-010-9436-1. - DOI - PMC - PubMed
    1. Muhaidat N, Saleh S, Fram K, Nabhan M, Almahallawi N, Alryalat SA, et al. Prevalence of endometriosis in women undergoing laparoscopic surgery for various gynaecological indications at a Jordanian referral centre: gaining insight into the epidemiology of an important women's health problem. BMC Womens Health. 2021;21(1):381. doi: 10.1186/s12905-021-01530-y. - DOI - PMC - PubMed

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