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Review
. 2024 Jun 27:23:100299.
doi: 10.1016/j.metop.2024.100299. eCollection 2024 Sep.

Adropin: A crucial regulator of cardiovascular health and metabolic balance

S Rooban  1 , K A Arul Senghor  1 , V M Vinodhini  1 , J S Kumar  2
Affiliations
Review

Adropin: A crucial regulator of cardiovascular health and metabolic balance

S Rooban et al. Metabol Open. .

Abstract

Adropin, a peptide discovered in 2008, has gained recognition as a key regulator of cardiovascular health and metabolic balance. Initially identified for its roles in energy balance, lipid metabolism, and glucose regulation, adropin has also been found to improve cardiovascular health by enhancing endothelial function, modulating lipid profiles, and reducing oxidative stress. These protective mechanisms suggest that adropin may be able to help prevent conditions such as atherosclerosis, hypertension, and other cardiovascular diseases. Research has established connections between adropin and cardiovascular risk factors, such as obesity, insulin resistance, and dyslipidemia, positioning it as a valuable biomarker for evaluating cardiovascular disease risk. New studies highlight adropin's diagnostic and prognostic significance, showing that higher levels are linked to better cardiovascular outcomes, while lower levels are associated with a higher risk of cardiovascular diseases. This review aims to summarize current knowledge on adropin, emphasizing its significance as a promising focus in the intersection of cardiovascular health and metabolic health. By summarizing the latest research findings, this review aims to offer insights into the potential applications of adropin in both clinical practice and research, leading to a deeper understanding of its role in maintaining cardiovascular and metabolic health.

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Conflict of interest statement

During the preparation of this work, the author(s) used Quillbot in order to improve writing language. After using quillbot, the author(s) reviewed and edited the content as needed and take(s) full responsibility for the content of the publication.

Figures

Fig. 1
Fig. 1
Structure of the Enho gene and adropin expression.
Fig. 2
Fig. 2
Metabolic regulation of glucose by adropin.
Fig. 3
Fig. 3
Adropin interaction with metabolic regulators (A: Adropin interaction with adiponectin, b: Adropin interaction with AMP-activated protein kinase).
Fig. 4
Fig. 4
Flowchart of adropin interaction with AMPK in Lipid homeostasis.
Fig. 5
Fig. 5
Graphical Representation of the mechanism of Adropin in neurodegenerative diseases.
Fig. 6
Fig. 6
Adropin-induced nitric oxide (NO) generation in endothelial cells (EC) enhances vascular smooth muscle cell (VSMC) actin depolymerization and decreased stiffness.
Fig. 7
Fig. 7
Adropin serves an anti-inflammatory function in a range of tissues.
See this image and copyright information in PMC

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