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. 2024 Jul 19;70(6):e20231673.
doi: 10.1590/1806-9282.20231673. eCollection 2024.

A new insight into the pathway behind spontaneous recurrent pregnancy loss: decreased CYR61 gene expression

Fahri Burcin Firatligil  1 , Burcu Firatligil Yildirir  2   3 , Ozden Yalcin-Ozuysal  3
Affiliations

A new insight into the pathway behind spontaneous recurrent pregnancy loss: decreased CYR61 gene expression

Fahri Burcin Firatligil et al. Rev Assoc Med Bras (1992). .

Abstract

Objective: Investigating the potential role of CYR61 in recurrent pregnancy loss is critical for developing diagnostic approaches and treatments for recurrent pregnancy loss.

Methods: In this prospective case-control study, we have investigated the expression patterns of CYR61 in blood samples from participants with recurrent pregnancy loss in their medical history and control group (n=20 vs n=10). Peripheral blood mononuclear cells from study and control groups were isolated and the expression patterns of the CYR61 gene were determined by real-time semi-quantitative reverse transcriptase PCR.

Results: A significant decrease in CYR61 gene expression was demonstrated in patients with two or more clinically recognized miscarriages compared with patients without miscarriages or with a history of miscarriage (p<0.01), which may make the CYR61 gene a potential candidate for predicting the risk of recurrent pregnancy loss.

Discussion: This study provides a basis for a detailed investigation of candidate biomarkers and molecular players involved in the development of recurrent pregnancy loss and for the development of potential treatment approaches to prevent recurrent pregnancy loss.

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Conflict of interest statement

Conflicts of interest: the authors declare there is no conflicts of interest.

Figures

Figure 1
Figure 1. The expression profile of CYR61 in patients in both groups. The relative mRNA expression levels of the CYR61 gene are shown (experiments were performed in triplicate and repeated thrice). ***p<0.01.
See this image and copyright information in PMC

References

    1. Liu Y, Zhang F, Dai L. C677T polymorphism increases the risk of early spontaneous abortion. J Assist Reprod Genet. 2019;36(8):1737–1741. doi: 10.1007/s10815-019-01500-2. - DOI - PMC - PubMed
    1. Rouse CE, Eckert LO, Babarinsa I, Fay E, Gupta M, Harrison MS, et al. Spontaneous abortion and ectopic pregnancy: Case definition & guidelines for data collection, analysis, and presentation of maternal immunization safety data. Vaccine. 2017;35(48 Pt A):6563–6574. doi: 10.1016/j.vaccine.2017.01.047. - DOI - PMC - PubMed
    1. Xu Y, Ban Y, Ran L, Yu Y, Zhai S, Sun Z, et al. Relationship between unexplained recurrent pregnancy loss and 5,10-methylenetetrahydrofolate reductase) polymorphisms. Fertil Steril. 2019;111(3):597–603. doi: 10.1016/j.fertnstert.2018.11.011. - DOI - PubMed
    1. Abu-Asab NS, Ayesh SK, Ateeq RO, Nassar SM, El-Sharif WA. Association of inherited thrombophilia with recurrent pregnancy loss in palestinian women. Obstet Gynecol Int. 2011;2011:689684–689684. doi: 10.1155/2011/689684. - DOI - PMC - PubMed
    1. Saravelos SH, Li TC. Unexplained recurrent miscarriage: how can we explain it? Hum Reprod. 2012;27(7):1882–1886. doi: 10.1093/humrep/des102. - DOI - PubMed

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