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Editorial
. 2024 Aug;44(8):1719-1724.
doi: 10.1161/ATVBAHA.124.320148. Epub 2024 Jul 24.

Reflections on Targeting Neutrophil Extracellular Traps in Deep Vein Thrombosis

Kimberly Martinod  1 , Denisa D Wagner  2   3   4
Affiliations
Editorial

Reflections on Targeting Neutrophil Extracellular Traps in Deep Vein Thrombosis

Kimberly Martinod et al. Arterioscler Thromb Vasc Biol. 2024 Aug.
No abstract available

Keywords: extracellular traps; inflammasomes; models, animal; venous thromboembolism; venous thrombosis.

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Conflict of interest statement

K. Martinod and D.D. Wagner are inventors on patents related to NET targeting in thrombosis. K. Martinod has received consulting fees from and has sponsored research agreements with Peel Therapeutics, Inc. D.D. Wagner is on the Scientific Advisory Board of Neutrolis, and her laboratory had sponsored research agreements for testing inhibitors of PAD4 and rhADAMTS13 in thrombosis.

Figures

Figure 1.
Figure 1.. Schematic representation of key molecular and cellular interactions in deep vein thrombosis (DVT) onset.
ADAMTS13, a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13; ASC, apoptosis-associated speck like protein containing a caspase recruitment domain; DNase, deoxyribonuclease; GP1b, glycoprotein 1b; GSDMD, gasdermin D; H, histone; HMGB1, high mobility group box 1; Jak2, Janus-associated kinase 2; NE, neutrophil elastase; NETs, neutrophil extracellular traps; PAD4, peptidylarginine deiminase 4; PSGL1, P-selectin glycoprotein ligand 1; RBC, red blood cell; TF, tissue factor; TGFβ, transforming growth factor β; VWF, von Willebrand factor.
Figure 2.
Figure 2.. Cross-section of an occluded vessel showing von Willebrand factor (VWF) tethering the thrombus to the vessel wall through interactions with neutrophil extracellular traps (NETs).
Experimental deep vein thrombosis was induced by balloon catheterization of the iliac vein in a baboon model. DNA is stained in green (panels A and B) and VWF in red (panel B). The white dashed line depicts the vessel wall, and panel B highlights the tethering of NET DNA (diffuse green staining pattern) within the thrombus to the vessel wall by VWF. Image reprinted with adaptations from Fuchs et al., PNAS 2010
See this image and copyright information in PMC

References

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