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. 2025 Jan 1;32(1):88-99.
doi: 10.5551/jat.64942. Epub 2024 Jul 24.

Lung Cancer Biomarkers Associated with Increased Peripheral Arterial Stiffness in Middle-aged Chinese Adults

Yun Li  1 , Jian-Wei Gu  2 , Jun-Xiang Li  2 , Fang-Yuan Chen  2 , Xiao-Qing Zhang  2 , Ju-Hua Liu  2
Affiliations

Lung Cancer Biomarkers Associated with Increased Peripheral Arterial Stiffness in Middle-aged Chinese Adults

Yun Li et al. J Atheroscler Thromb. .

Abstract

Aims: Previous evidence suggests that serum lung cancer biomarkers are associated with inflammatory conditions; however, their relationship with peripheral arterial stiffness remains unclear. Therefore, the present study investigated the relationship between serum lung cancer biomarkers and peripheral arterial stiffness in middle-aged Chinese adults.

Methods: In total, 3878 middle-aged Chinese adults were enrolled in this study. Increased peripheral arterial stiffness was assessed using the brachial-ankle pulse wave velocity and ankle-brachial index. Univariate and multivariate logistic regression analyses were used to determine the independent effects of serum lung cancer biomarkers on the risk of increased peripheral arterial stiffness. A receiver operating characteristic curve analysis was used to assess the diagnostic ability of serum lung cancer biomarkers in distinguishing increased peripheral arterial stiffness.

Results: Serum levels of carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), cytokeratin-19 fragment 21-1, and pro-gastrin-releasing peptide were higher in subjects with increased peripheral arterial stiffness than in those without (P＜0.05). After adjusting for other risk factors, serum CEA and NSE levels were found to be independently associated with increased peripheral arterial stiffness. The corresponding adjusted odds ratios (ORs) for increased peripheral arterial stiffness in CEA level quartiles were 1.00, 1.57, 2.15, and 6.13. The ORs for increased peripheral arterial stiffness in the quartiles of NSE levels were 1.00, 4.92, 6.65, and 8.01.

Conclusions: Increased serum CEA and NSE levels are closely linked to increased peripheral arterial stiffness, and high serum CEA and NSE levels are potential risk markers for peripheral arterial stiffness in middle-aged Chinese adults.

Keywords: Carcinoembryonic antigen; Middle-aged Chinese adults; Neuron-specific enolase; Peripheral arterial stiffness.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig.1. The percentage of subjects with increased peripheral arterial stiffness according to the quartiles of the serum CEA and NSE levels
Fig.1. The percentage of subjects with increased peripheral arterial stiffness according to the quartiles of the serum CEA and NSE levels
Abbreviations: CEA, carcinoembryonic antigen; NSE, neuron-specific enolase.
Fig.2. Receiver operating characteristic curves for the diagnostic value of CEA and NSE for increased peripheral arterial stiffness
Fig.2. Receiver operating characteristic curves for the diagnostic value of CEA and NSE for increased peripheral arterial stiffness
Abbreviations: Similar to Figure 1
See this image and copyright information in PMC

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