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. 2024 Oct;31(10):6831-6840.
doi: 10.1245/s10434-024-15876-8. Epub 2024 Jul 24.

Patient-Reported Outcomes 10 Years After Breast-Conserving Surgery for Early-Stage Breast Cancer

Laura S Dominici  1   2   3 , Alison Laws  1   2   3   4 , Mirelle Lagendijk  1   2   5 , Samantha Grossmith  1   2 , Melissa Hughes  2 , Nancy Lin  2   3   6 , Elizabeth A Mittendorf  1   2   3 , Tari A King  7   8   9
Affiliations

Patient-Reported Outcomes 10 Years After Breast-Conserving Surgery for Early-Stage Breast Cancer

Laura S Dominici et al. Ann Surg Oncol. 2024 Oct.

Erratum in

Abstract

Background: Patient-reported outcomes (PROs) are a critical component of value-based care. Limited data exist describing long-term PROs in patients undergoing breast-conserving surgery (BCS).

Patients and methods: Patients undergoing surgery for stage 0-III breast cancer at our institution from 2002 to 2012 who agreed to be contacted were invited to participate in a cross-sectional PRO study. Health-related quality of life outcomes using BREAST-Q, EORTC QLQ-C30, and EORTC QLQ-BR45 were collected. Patients reporting chemotherapy within 6 months of receiving the survey were excluded. For this work, we focused on patients who underwent BCS. Multivariable linear regression was performed to identify factors associated with PRO scores, adjusting for age, time since surgery, anatomic stage, molecular subtype, receipt of systemic and/or radiation therapy (RT), locoregional recurrence, or contralateral breast cancer.

Results: Among 562 interested and eligible patients, 437 (78%) responded; median time from surgery to survey completion was 10.4 years (interquartile range: 8.0-13.5). Median age at surgery was 53 years (standard deviation 9.8 years), ≥ 90% were white, had upfront surgery for early-stage disease, and completed adjuvant RT. Physical and psychological well-being scores were generally high, with more variation seen for sexual well-being and satisfaction with breasts.

Conclusion: This study provides long-term PRO data for patients treated with BCS, demonstrating the ongoing association of breast cancer surgery with quality of life in the survivorship period and highlighting the importance of examining PROs beyond the perioperative period. These data also provide important reference values for the interpretation of PROs among women treated with BCS as we move towards value-based care.

Keywords: Breast cancer; Breast-conserving surgery; Patient-reported outcomes; Quality of life; Survivorship.

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Figures

Figure 1.
Figure 1.
BREAST-Q 10 years after Breast-Conserving Surgery for Early-Stage Breast Cancer (2002–2012) • 1a. BREAST-Q Physical Well-being Score (N=436) • 1b. BREAST-Q Psychological Well-being Score (N=436) • 1c. BREAST-Q Sexual Well-being Score (N=370) • 1d. BREAST-Q Satisfaction With Breasts Score (N=434)
Figure 2.
Figure 2.
Adjusted associations of demographic, tumor, and treatment factors with BREAST-Q scores 10 years after breast-conserving surgery (2002–2012) • 2a. Satisfaction with Breasts Score • 2b. Physical Well-Being Score • 2c. Psychological Well-being Score • 2d. Sexual Well-being Score Abbreviation: HR-negative, hormone receptor-negative
Figure 3.
Figure 3.
EORTC QLQ C30 10 years after Breast Conserving Surgery for Early-Stage Breast Cancer (2002–2012) • 3a. EORTC QLQ30 Global Health Status (N=436) • 3b. EORTC QLQ30 Physical Function (N=435) • 3c. EORTC QLQ30 Pain Scores (N=436) Abbreviation: EORTC, European Organisation for Research and Treatment of Cancer
Figure 4.
Figure 4.
EORTC QLQ-BR23 10 years after Breast Conserving Surgery for Early-Stage Breast Cancer (2002–2012) • 4a. EORTC BR23 Body Image (N=434) • 4b. EORTC BR23 Sexual Function (N=396) • 4c. EORTC BR23 Breast Symptoms (N=432) Abbreviation: EORTC, European Organisation for Research and Treatment of Cancer
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References

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