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. 2024 Dec 1;109(12):4067-4072.
doi: 10.3324/haematol.2023.283798.

Co-shared genomic alterations within tumors from patients with both myeloproliferative neoplasms and lymphoma

Johanne M Holst  1 , Martin B Pedersen  1 , Marie B Enemark  1 , Marcus C Hansen  2 , Patrick R Noerhave  1 , Trine L Plesner  3 , Henrik Frederiksen  4 , Michael B Moeller  5 , Stephen J Hamilton-Dutoit  6 , Peter Noergaard  7 , Bo K Mortensen  8 , Hans B Ommen  1 , Jesper Stentoft  1 , Wayne Tam  9 , Maja Ludvigsen  1 , Wing C Chan  10 , Nicolai J Birkbak  11 , Giorgio Inghirami  9 , Francesco D'Amore  12
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Co-shared genomic alterations within tumors from patients with both myeloproliferative neoplasms and lymphoma

Johanne M Holst et al. Haematologica. .
No abstract available

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Figures

Figure 1.
Figure 1.
Overview of shared and private mutations in the study cohort. Shared and private mutations with variant allele frequencies (VAF) ≥10% identified by whole exome sequencing. Canonical myeloproliferative neoplasm (MPN) and lymphoma-entity associated mutations are also reported at lower VAF levels. The numbers in the individual boxes indicate VAF (%). (A) Mutations identified in patients with angioimmunoblastic T-cell lymphoma (AITL) and MPN. §In patient #5, MPN and AITL were diagnosed simultaneously. The bone marrow was morphologically and immunohistochemically found to be infiltrated by both neoplasms. The mutational findings in this patient should therefore be interpreted with caution. (B) Mutations identified in patients with diffuse large B-cell lymphoma (DLBCL) and MPN. #Identical variant found in non-neoplastic tissue (germline mutation). *According to International Cancer Genome Consortium terminology, www.dcc.icgc.org. AITL: angioimmunoblastic T-cell lymphoma; DLBCL: diffuse large B-cell lymphoma; M: myeloid sample; L: lymphoid sample.
See this image and copyright information in PMC

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