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Meta-Analysis
. 2024 Mar 11;20(4):221-228.
doi: 10.1080/14796678.2024.2352308. Epub 2024 Jun 6.

Evaluating the efficacy of ubiquinol in heart failure patients: a systematic review and meta-analysis

Shurjeel Uddin Qazi  1 , Muhammad Ahrar Bin Naeem  2 , Muhammad Umar  2 , Muhammad Jawad Zahid  3 , Mah I Kan Changez  4 , Laraib Iqbal  5 , Ismail Abdur Rahman Khan Sherwani  6 , Hassan Mehmood  2 , Abeera Farooq Abbasi  1 , Amna Zahid  7 , Prinka Perswani  8 , Jishanth Mattumpuram  9
Affiliations
Meta-Analysis

Evaluating the efficacy of ubiquinol in heart failure patients: a systematic review and meta-analysis

Shurjeel Uddin Qazi et al. Future Cardiol. .

Abstract

Aim: We aim to analyze past literature to evaluate the efficacy of coenzyme Q10 (CoQ-10) in the population with heart failure (HF). Methods: A systematic literature search was conducted through MEDLINE (via PubMed) and Cochrane Library. The outcomes analyzed were a reduction in HF-related mortality, an improvement in exercise capacity, and the left ventricular ejection fraction (LVEF). Results: Among 16 studies, CoQ-10 significantly reduced HF-related mortality by 40% and improved exercise capacity in patients with HF, but demonstrated no significant difference in LVEF however, the potential of its efficacy on LVEF could not be ruled out. Conclusion: CoQ-10 significantly enhances exercise capacity and reduces HF-related mortality; however, its impact on patients with reduced LVEF requires further investigation.

Keywords: CoQ-10; cardiovascular disorders; coenzyme Q10; heart failure; ubiquinol.

Plain language summary

[Box: see text].

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Conflict of interest statement

The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Figures

Figure 1.
Figure 1.
Prisma flowchart showing the process of data collection.
Figure 2.
Figure 2.
Efficacy of coenzyme-Q10 in reducing mortality in heart failure patients. 95% CI: 95% confidence interval and and I2 statistics; Co-Q: Coenzyme-Q10; RR: Risk ratio.
Figure 3.
Figure 3.
Efficacy of coenzyme-Q10 on exercise capacity. 95% CI: 95% Confidence interval and I2 statistics; Co-Q: Coenzyme-Q10; SD: Standard deviation; SMD: Standardized mean difference.
Figure 4.
Figure 4.
Efficacy of coenzyme-Q10 on the ejection fraction in heart failure patients. 95% CI: 95% Confidence interval and I2 statistics; Co-Q: Coenzyme-Q10; SD: Standard deviation; SMD: Standardized mean difference.
See this image and copyright information in PMC

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