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. 2024 Jun 3;20(3):997-1001.
doi: 10.5114/aoms/189575. eCollection 2024.

Efficacy of statin therapy in reducing epicardial adipose tissue: a systematic review and meta-analysis

Tannaz Jamialahmadi  1   2 , Luis E Simental-Mendia  3 , Ali H Eid  4 , Wael Almahmeed  5 , Sepideh Salehabadi  2 , Khalid Al-Rasadi  6 , Maciej Banach  7   8 , Amirhossein Sahebkar  9   10   11
Affiliations

Efficacy of statin therapy in reducing epicardial adipose tissue: a systematic review and meta-analysis

Tannaz Jamialahmadi et al. Arch Med Sci. .

Abstract

Introduction: Understanding the effect of statins on epicardial adipose tissue (EAT) is important as it may help reduce the negative impact of EAT-derived molecules on the cardiovascular system and consequently on coronary artery disease. Thus, we aimed to perform a systematic review and meta-analysis to assess the impact of statin therapy on EAT.

Methods: The study utilized Scopus, PubMed, Embase, and Web of Science to gather relevant studies on the impacts of statins on EAT until September 5th, 2023. The data collected underwent meta-analysis using Comprehensive Meta-Analysis (CMA) V4 software.

Results: In the meta-analysis, three studies involving 512 subjects were ultimately incorporated. The findings indicated a significant decrease in EAT after treatment with statins (standardized mean difference (SMD = -0.507, 95% CI: -2.536, 1.521, p = 0.021).

Conclusions: Statins appear to exert an additional cardiovascular therapeutic effect by reducing EAT.

Keywords: cardiovascular disease; coronary artery disease; epicardial adipose tissue; statin; systematic review.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow chart of the number of studies selected for meta-analysis
Figure 2
Figure 2
Meta-analysis of the effects of statins on EAT in RCTs
See this image and copyright information in PMC

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