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. 2024 Jun 20;10(13):e33350.
doi: 10.1016/j.heliyon.2024.e33350. eCollection 2024 Jul 15.

Global research trends in precision-targeted therapies for systemic lupus erythematosus (2003-2023): A bibliographic study

Zengze Yuan  1 , Weiqing Zhang  1 , Zhaokai Jin  2 , Yihan Wang  1 , Zhiting Lin  1 , Zhimin Xie  3 , Xinchang Wang  3
Affiliations

Global research trends in precision-targeted therapies for systemic lupus erythematosus (2003-2023): A bibliographic study

Zengze Yuan et al. Heliyon. .

Abstract

Background: Systemic lupus erythematosus (SLE) is a persistent inflammatory disease caused by an autoimmune response that predominantly affects multiple organs and systems. Growing evidence highlights the critical role of precision-targeted therapies in the management of SLE. Surprisingly, only a handful of bibliometric studies have thoroughly assessed this area. This study attempts to assess the global landscape of literature output and research trends related to precision-targeted therapy for SLE.

Method: Publications related to precision-targeted therapy for SLE from 2003 to 2023 were searched in the Web of Science Core Collection (WoSCC) database. VOSviewers, CiteSpace and the R package "bibliometrix" were used to perform this bibliometric analysis.

Results: A total of 3700 papers were retrieved, showing a steady annual increase in publications from 2003 to 2022. The United States led the field with the highest number of papers (36.1 %) and secured the top position in terms of citation frequency (59,889) and H-index (115). Anhui Medical University System claimed the top spot with an impressive output of 70 papers. Principal investigators Tsokos, George C. C., and Lu, Qianjin led the research effort. Among the journals, Frontiers in Immunology stood out, publishing the highest number of articles with 191. In particular, precision-targeted therapy for SLE has become a major research focus in recent years, covering aspects such as T cells, B cells, oxidative stress, remission, and PHASE-III.

Conclusion: This bibliometric study of ours systematically analyses research trends in precision targeted therapy for systemic lupus erythematosus, and this information identifies the research frontiers and hot directions in recent years and will serve as a reference for scientists working on targeted therapies.

Keywords: Bibliometric analysis; Citespace; Systemic lupus erythematosus; Targeted therapy; VOSviewers.

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Conflict of interest statement

The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Xinchang Wang reports financial support was provided by The Second Affiliated Hospital of 10.13039/501100004863Zhejiang Chinese Medical University. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Flowchart of selected publications for this study.
Fig. 2
Fig. 2
Trend of the number of articles published annually and the total amount of citations of annual articles.
Fig. 3
Fig. 3
(A) Visualization map of the country citation network produced by the VOS viewer (version 5.8 R3). China, people's republic of china.England, united kingdom.(B) The geographical distribution.
Fig. 4
Fig. 4
(A) Visualization map of the institutions' collaboration network produced by the VOS viewer (version 5.8 R3) (B) The institutions' citation network visualization map generated by VOS viewer (version5.8 R3).
Fig. 5
Fig. 5
(A) The authors' collaboration network visualization map generated by VOS viewer (version5.8 R3). (B) The authors' co-citation network visualization map generated by VOS viewer (version5.8 R3).
Fig. 6
Fig. 6
A dual-map overlay of the relevant journals generated by CiteSpace V (version5.8 R3).
Fig. 7
Fig. 7
The top 25 references with the strongest citation. (The green line segment represents the time interval, and the red line segment represents the active time). (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Fig. 8
Fig. 8
(A) The network visualization map of keywords produced by VOS viewer (version5.8 R3). (B) Trend topic analysis.
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