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Review
. 1985 Nov:(200):100-13.

Fracture healing perspectives

D J Simmons
  • PMID: 3905103
Review

Fracture healing perspectives

D J Simmons. Clin Orthop Relat Res. 1985 Nov.

Abstract

This paper reviews the sequence of histomorphologic changes that occur in and around a fracture site, and discusses recent concepts about the roles of the cells and bone matrical moieties in promoting specific cell transformations during the phases of callus tissue formation and consolidation of the bony cortex. Current knowledge about the roles of autocrine, paracrine, and endocrine polypeptide growth and transforming factors lends new perspectives about this classic problem in bone physiology.

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