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Editorial
. 2024 Dec;71(6):625-627.
doi: 10.1165/rcmb.2024-0306ED.

Respiratory Epithelial Cell Surface Decoration Provides Defense against Bacterial Damage during Infection

Harriet R Ellis  1 , Luke P Allsopp  1
Affiliations
Editorial

Respiratory Epithelial Cell Surface Decoration Provides Defense against Bacterial Damage during Infection

Harriet R Ellis et al. Am J Respir Cell Mol Biol. 2024 Dec.
No abstract available

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Figures

Figure 1.
Figure 1.
Degradation of heparan sulfate or hyaluronan worsens Streptococcus pneumoniae lung infection. (A) Visual summary of approach used by Goekeri and colleagues (3). Briefly, mice were inoculated with S. pneumoniae or PBS in combination with heparinise or hyaluronidase and monitored for 48 hours. (B) Diagram depicting surface display of heparan sulphate and hyaluronan on the lung epithelial cell membrane. (C) Summary table of main findings of Goekeri et al. including changes to bacterial burden, severity of disease, dissemination and host immune response to infection by S. pneumoniae in the presence of heparinise or hyaluronidase compared to S. pneumoniae alone. BALF = BAL fluid; CXCL1 = C-X-C motif chemokine ligand 1; CXCL5 = C-X-C motif chemokine ligand 5; GAG = glycosaminoglycan; Ly6Chi = inflammatory monocytes.
See this image and copyright information in PMC

Comment on

References

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    1. Goekeri C, Linke KAK, Hoffmann K, Lopez-Rodriguez E, Gluhovic V, Voß A, et al. Enzymatic modulation of the pulmonary glycocalyx enhances susceptibility to Streptococcus pneumoniae. Am J Respir Cell Mol Biol . 2024;71:646–658. - PMC - PubMed
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