Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2024 Jul 25;230(1):e75-e79.
doi: 10.1093/infdis/jiad502.

Differences in Rotavirus Shedding and Duration by Infant Oral Rotavirus Vaccination Status in Dhaka, Bangladesh, 2011-2014

Jenna Ciszewski  1 , Mami Taniuchi  2   3   4 , Benjamin Lee  5 , E Ross Colgate  6 , James A Platts-Mills  2 , Rashidul Haque  7 , K Zaman  7 , Benjamin Lopman  1 , William A Petri Jr  2 , Beth D Kirkpatrick  6 , Elizabeth T Rogawski McQuade  1
Affiliations
Randomized Controlled Trial

Differences in Rotavirus Shedding and Duration by Infant Oral Rotavirus Vaccination Status in Dhaka, Bangladesh, 2011-2014

Jenna Ciszewski et al. J Infect Dis. .

Abstract

To evaluate how breakthrough rotavirus disease contributes to transmission, we examined the impact of rotavirus vaccination on fecal shedding and duration of illness. We used multivariable linear regression to analyze rotavirus quantity by RT-qPCR and duration among 184 episodes of rotavirus diarrhea positive by ELISA in the PROVIDE study. Vaccinated children had less fecal viral shedding compared to unvaccinated children (mean difference = -0.59 log copies per gram of stool; 95% confidence interval [CI], -.99 to -.19). Duration of illness was on average 0.47 days (95% CI, -.23 to 1.17 days) shorter among vaccinated children. Rotarix vaccination reduces shedding burden among breakthrough cases of rotavirus gastroenteritis. Clinical Trials Registration . NCT01375647.

Keywords: diarrhea; enteric infections; rotavirus; vaccination.

PubMed Disclaimer

Conflict of interest statement

Potential conflicts of interest. B. Lopman reports personal fees outside the submitted work from Epidemiologic Research Methods, LLC and Hillevax, Inc. All other authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

References

    1. Troeger C, Khalil IA, Rao PC, et al. Rotavirus vaccination and the global burden of rotavirus diarrhea among children younger than 5 years. JAMA Pediatr 2018; 172:958–65. - PMC - PubMed
    1. World Health Organization . Rotavirus vaccines: an update. Wkly Epidemiol Rec 2009; 84:533–7. - PubMed
    1. Burnett E, Jonesteller CL, Tate JE, Yen C, Parashar UD. Global impact of rotavirus vaccination on childhood hospitalizations and mortality from diarrhea. J Infect Dis 2017; 215:1666–72. - PMC - PubMed
    1. Parashar UD, Johnson H, Steele AD, Tate JE. Health impact of rotavirus vaccination in developing countries: progress and the way forward. Clin Infect Dis 2016; 62(Suppl 2):S91–5. - PMC - PubMed
    1. Burnett E, Parashar UD, Tate JE. Real-world effectiveness of rotavirus vaccines, 2006–19: a literature review and meta-analysis. Lancet Glob Health 2020; 8:e1195–202. - PMC - PubMed

Publication types

MeSH terms

Associated data