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Clinical Trial
. 1979 Sep;55(646):537-40.
doi: 10.1136/pgmj.55.646.537.

Dose response for blood pressure and degree of cardiac beta-blockade with atenolol

A J Marshall, D W Barritt, S Heaton, J D Harry
Clinical Trial

Dose response for blood pressure and degree of cardiac beta-blockade with atenolol

A J Marshall et al. Postgrad Med J. 1979 Sep.

Abstract

The hypotensive effect of 25 mg, 50 mg, 75 mg, 100 mg and 0 mg of atenolol daily were compared in a double-blind within-patient study. The fall in blood pressure with 25 mg daily was not significantly different than with 100 mg. The dose response curve lies between 0 and 25 mg daily. Cardiac beta-blockade (measured by suppression of exercise tachycardia) was not maximal with 25 mg of atenolol daily. The dose response curves for beta-blockade and the hypotensive effect are not parallel.

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References

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    1. Postgrad Med J. 1977;53 Suppl 3:173-5 - PubMed
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    1. Postgrad Med J. 1977;53 Suppl 3:70-3 - PubMed

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