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Review
. 2024 Nov-Dec;69(6):836-846.
doi: 10.1111/jmwh.13674. Epub 2024 Jul 25.

Clinical Applications of Fetal Cell-Free DNA: State of the Science

Julie Knutson  1 , Kathryn Anthony  2 , Melissa L Russo  3 , Martha B Kole-White  3
Affiliations
Review

Clinical Applications of Fetal Cell-Free DNA: State of the Science

Julie Knutson et al. J Midwifery Womens Health. 2024 Nov-Dec.

Abstract

Advances in technology have correlated with expanding prenatal genetic testing options for pregnant people. Leading medical organizations recommend cell-free DNA as the most sensitive screening test for trisomies 13, 18, and 21, as well as for fetal sex chromosome aneuploidies. The commercially available testing options go beyond these recommended tests, and prenatal care professionals should be familiar with the tests that their patients may choose despite being beyond the scope of current medical recommendations. This article explains updates in cell-free DNA technology and clinical considerations for prenatal care professionals, recognizing that this is a rapidly changing field of science and health care.

Keywords: cell‐free DNA (cfDNA); noninvasive prenatal screening (NIPS); noninvasive prenatal testing (NIPT); prenatal genetic testing.

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References

REFERENCES

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