Pre-diagnostic plasma advanced glycation end-products and soluble receptor for advanced glycation end-products and mortality in colorectal cancer patients

Jinze Li¹, Jacqueline Roshelli Baker², Elom K Aglago³, Zhiwei Zhao⁴, Li Jiao⁵, Heinz Freisling³, David J Hughes⁶, Anne Kirstine Eriksen^{7

8}, Anne Tjønneland^{7

8}, Gianluca Severi^{9

10}, Verena Katzke¹¹, Rudolf Kaaks¹¹, Matthias B Schulze^{12

13}, Giovanna Masala¹⁴, Valeria Pala¹⁵, Fabrizio Pasanisi¹⁶, Rosario Tumino¹⁷, Lisa Padroni¹⁸, Roel C H Vermeulen¹⁹, Inger T Gram²⁰, Tonje Braaten²⁰, Paula Gabriela Jakszyn²¹, Maria-José Sánchez^{22

23

24}, Jesús-Humberto Gómez-Gómez^{24

25}, Conchi Moreno-Iribas^{24

26

27}, Pilar Amiano^{24

28

29}, Keren Papier³⁰, Elisabete Weiderpass³¹, Inge Huybrechts³, Alicia K Heath³², Casper Schalkwijk³³, Mazda Jenab³, Veronika Fedirko^{1

2}

Affiliations

¹ Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
² Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
³ Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France.
⁴ Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
⁵ Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
⁶ Cancer Biology and Therapeutics Group, School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland.
⁷ Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
⁸ Danish Cancer Society Research Center, Copenhagen, Denmark.
⁹ Paris-Saclay University, UVSQ, Inserm, Gustave Roussy, CESP, Villejuif, France.
¹⁰ Department of Statistics, Computer Science, Applications "G. Parenti", University of Florence, Florence, Italy.
¹¹ Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
¹² Department of Molecular Epidemiology, German Institute for Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
¹³ Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany.
¹⁴ Clinical Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network, Florence, Italy.
¹⁵ Epidemiology and Prevention Unit Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milano, Italy.
¹⁶ Dipartimento Di Medicina Clinica E Chirurgia, Federico II University, Naples, Italy.
¹⁷ Hyblean Association for Epidemiological Research, AIRE ONLUS, Ragusa, Italy.
¹⁸ Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital, and Center for Cancer Prevention (CPO), Turin, Italy.
¹⁹ Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.
²⁰ Faculty of Health Sciences, Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
²¹ Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain.
²² Escuela Andaluza de Salud Pública (EASP), Granada, Spain.
²³ Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain.
²⁴ CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain.
²⁵ Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia, Spain.
²⁶ Instituto de Salud Pública y Laboral de Navarra, Pamplona, Spain.
²⁷ Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
²⁸ Ministry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa, San Sebastian, Spain.
²⁹ BioGipuzkoa (BioDonostia) Health Research Institute, Epidemiology of Chronic and Communicable Diseases Group, San Sebastián, Spain.
³⁰ Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
³¹ International Agency for Research on Cancer, World Health Organization, Lyon, France.
³² Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
³³ Laboratory of Metabolism and Vascular Medicine, Department of Internal Medicine, Maastricht University Medical Center, The Netherlands.

PMID: 39057841
DOI: 10.1002/ijc.35114

Pre-diagnostic plasma advanced glycation end-products and soluble receptor for advanced glycation end-products and mortality in colorectal cancer patients

Jinze Li et al. Int J Cancer. 2024.

. 2024 Dec 1;155(11):1982-1995.

doi: 10.1002/ijc.35114. Epub 2024 Jul 26.

Authors

Affiliations

¹ Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
² Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
³ Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France.
⁴ Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
⁵ Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
⁶ Cancer Biology and Therapeutics Group, School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland.
⁷ Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
⁸ Danish Cancer Society Research Center, Copenhagen, Denmark.
⁹ Paris-Saclay University, UVSQ, Inserm, Gustave Roussy, CESP, Villejuif, France.
¹⁰ Department of Statistics, Computer Science, Applications "G. Parenti", University of Florence, Florence, Italy.
¹¹ Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
¹² Department of Molecular Epidemiology, German Institute for Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
¹³ Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany.
¹⁴ Clinical Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network, Florence, Italy.
¹⁵ Epidemiology and Prevention Unit Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milano, Italy.
¹⁶ Dipartimento Di Medicina Clinica E Chirurgia, Federico II University, Naples, Italy.
¹⁷ Hyblean Association for Epidemiological Research, AIRE ONLUS, Ragusa, Italy.
¹⁸ Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital, and Center for Cancer Prevention (CPO), Turin, Italy.
¹⁹ Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.
²⁰ Faculty of Health Sciences, Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
²¹ Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain.
²² Escuela Andaluza de Salud Pública (EASP), Granada, Spain.
²³ Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain.
²⁴ CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain.
²⁵ Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia, Spain.
²⁶ Instituto de Salud Pública y Laboral de Navarra, Pamplona, Spain.
²⁷ Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
²⁸ Ministry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa, San Sebastian, Spain.
²⁹ BioGipuzkoa (BioDonostia) Health Research Institute, Epidemiology of Chronic and Communicable Diseases Group, San Sebastián, Spain.
³⁰ Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
³¹ International Agency for Research on Cancer, World Health Organization, Lyon, France.
³² Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
³³ Laboratory of Metabolism and Vascular Medicine, Department of Internal Medicine, Maastricht University Medical Center, The Netherlands.

PMID: 39057841
DOI: 10.1002/ijc.35114

Abstract

Advanced glycation end-products (AGEs), formed endogenously or obtained exogenously from diet, may contribute to chronic inflammation, intracellular signaling alterations, and pathogenesis of several chronic diseases including colorectal cancer (CRC). However, the role of AGEs in CRC survival is less known. The associations of pre-diagnostic circulating AGEs and their soluble receptor (sRAGE) with CRC-specific and overall mortality were estimated using multivariable-adjusted Cox proportional hazards regression among 1369 CRC cases in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Concentrations of major plasma AGEs, N^ε-[carboxy-methyl]lysine (CML), N^ε-[carboxy-ethyl]lysine (CEL) and N^δ-[5-hydro-5-methyl-4-imidazolon-2-yl]-ornithine (MG-H1), were measured using ultra-performance liquid chromatography mass-spectrometry. sRAGE was assessed by enzyme-linked immunosorbent assay. Over a mean follow-up period of 96 months, 693 deaths occurred of which 541 were due to CRC. Individual and combined AGEs were not statistically significantly associated with CRC-specific or overall mortality. However, there was a possible interaction by sex for CEL (P_interaction = .05). Participants with higher sRAGE had a higher risk of dying from CRC (HR_Q5vs.Q1 = 1.67, 95% CI: 1.21-2.30, P_trend = .02) or any cause (HR_Q5vs.Q1 = 1.38, 95% CI: 1.05-1.83, P_trend = .09). These associations tended to be stronger among cases with diabetes (P_interaction = .03) and pre-diabetes (P_interaction <.01) before CRC diagnosis. Pre-diagnostic AGEs were not associated with CRC-specific and overall mortality in individuals with CRC. However, a positive association was observed for sRAGE. Our findings may stimulate further research on the role of AGEs and sRAGE in survival among cancer patients with special emphasis on potential effect modifications by sex and diabetes.

Keywords: advanced glycation end‐products (AGEs); colorectal cancer; mortality; soluble receptor of AGEs (sRAGE).

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References

REFERENCES

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Pre-diagnostic plasma advanced glycation end-products and soluble receptor for advanced glycation end-products and mortality in colorectal cancer patients

Affiliations

Pre-diagnostic plasma advanced glycation end-products and soluble receptor for advanced glycation end-products and mortality in colorectal cancer patients

Authors

Affiliations

Abstract

References

REFERENCES

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Medical