Conflict of Interest Disclosures: Dr Krumholz reported being a cofounder of medRxiv; receiving options for Element Science and Identifeye; receiving personal fees from F-Prime; being a cofounder of and holding equity in Hugo Health, Refactor Health, and ENSIGHT-AI; and being associated with research contracts through Yale University from Janssen, Kenvue, and Pfizer outside the submitted work. Dr Ross reported being a cofounder of medRxiv; receiving research support through Yale University from the US Food and Drug Administration (FDA), Johnson & Johnson, Arnold Ventures, Agency for Healthcare Research and Quality, and National Heart, Lung, and Blood Institute of the National Institutes of Health (NIH); being a Deputy Editor at JAMA; and being an expert witness at the request of Relator’s attorneys (the Greene Law Firm) in a qui tam suit alleging violations of the False Claims Act and Anti-Kickback Statute against Biogen Inc that was settled in September 2022 outside the submitted work. Dr Wallach reported receiving research support from Arnold Ventures, FDA, Johnson & Johnson through the Yale Open Data Access project, and the National Institute on Alcohol Abuse and Alcoholism of the NIH and serving as a consultant to Hagens Berman Sobol Shapiro LLP and Dugan Law Firm APLC outside the submitted work. No other disclosures were reported.