ENIGMA-Chronic Pain: a worldwide initiative to identify brain correlates of chronic pain

Yann Quidé^{1

2}, Neda Jahanshad³, Jamila Andoh⁴, Georgia Antoniou⁵, Apkar Vania Apkarian^{6

7

8}, Yoni K Ashar⁹, Bashar W Badran¹⁰, C Lexi Baird^{11

12}, Luke Baxter¹³, Tyler R Bell^{14

15}, Laura Blanco-Hinojo^{16

17}, Jeffrey Borckardt^{10

18

19}, Chloe L Cheung²⁰, Daniel Ciampi de Andrade²¹, Bruno A Couto²¹, Simon R Cox²², Yenisel Cruz-Almeida^{23

24

25}, Udo Dannlowski²⁶, Enrico De Martino²¹, Marina de Tommaso²⁷, Joan Deus^{16

28}, Martin Domin²⁹, Natalia Egorova-Brumley³⁰, James Elliott^{31

32

33}, Silvia Fanton^{34

35}, Camille Fauchon^{36

37}, Herta Flor³⁸, Carol E Franz^{14

15}, Justine M Gatt^{1

39

40}, Paul Gerdhem^{41

42

43}, Jodi M Gilman^{44

45}, Randy L Gollub^{34

44}, Varan Govind⁴⁶, Thomas Graven-Nielsen²¹, Gustaf Håkansson⁴¹, Tim Hales⁴⁷, Courtney Haswell^{11

12}, Nils Jannik Heukamp⁴⁸, Li Hu^{49

50}, Lejian Huang^{6

7}, Ahmed Hussain^{11

12}, Karin Jensen⁵¹, Tilo Kircher⁵², William S Kremen^{14

15}, Elisabeth J Leehr²⁶, Martin Lindquist⁵³, Marco L Loggia^{34

35

54}, Martin Lotze²⁹, Katherine T Martucci⁵⁵, Timothy J Meeker⁵⁶, Susanne Meinert^{26

57}, Samantha K Millard²¹, Rajendra A Morey^{11

12}, Carlos Murillo^{9

58}, Frauke Nees⁴⁸, Igor Nenadic⁵², Haeme R P Park^{1

39}, Xiaolong Peng¹⁰, Markus Ploner⁵⁹, Jesus Pujol¹⁶, Linda E Robayo⁶⁰, Teddy Salan⁴⁶, David A Seminowicz⁶¹, Angela Serian⁶², Rebeccah Slater¹³, Frederike Stein⁵², Jennifer Stevens^{63

64}, Sebastian Strauss⁶², Delin Sun^{11

12

65}, Etienne Vachon-Presseau^{66

67

68}, Pedro A Valdes-Hernandez²⁴, Sven Vanneste^{69

70

71}, Mark Vernon⁶⁴, Madeleine Verriotis^{72

73}, Tor D Wager⁷⁴, Eva Widerstrom-Noga⁶⁰, Anna Woodbury^{64

75}, Fadel Zeidan⁷⁶, Ravi R Bhatt³, Christopher R K Ching³, Elizabeth Haddad³, Sophia I Thomopoulos³, Paul M Thompson³, Sylvia M Gustin^{1

2}

Affiliations

¹ School of Psychology, The University of New South Wales (UNSW) Sydney, Sydney, NSW, Australia.
² Centre for Pain IMPACT, Neuroscience Research Australia, Randwick, NSW, Australia.
³ Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
⁴ Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
⁵ Division of Population Health and Genomics, Medical Research Institute, University of Dundee, Dundee, Scotland, United Kingdom.
⁶ Center for Translational Pain Research, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
⁷ Department of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
⁸ Department of Anesthesiology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
⁹ Department of General Internal Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
¹⁰ Department of Psychiatry and Behavioral Sciences, Neuro-X Lab, Medical University of South Carolina, Charleston, SC, United States.
¹¹ Duke-UNC Brain Imaging and Analysis Center, Duke University, Durham, NC, United States.
¹² VA Mid-Atlantic MIRECC, Durham VA Medical Center, Durham VA, Durham, NC, United States.
¹³ Department of Paediatrics, University of Oxford, Oxford, United Kingdom.
¹⁴ Department of Psychiatry, University of California, San Diego, CA, United States.
¹⁵ Center for Behavior Genetics of Aging, University of California, San Diego, CA, United States.
¹⁶ MRI Research Unit, Department of Radiology, Hospital del Mar, Barcelona, Spain.
¹⁷ IsGlobal, Barcelona, Spain.
¹⁸ Medical University of South Carolina, Charleston, SC, United States.
¹⁹ Ralph H. Johnson VAMC, Charleston, SC, United States.
²⁰ Neuroscience Graduate Program, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, Canada.
²¹ Center for Neuroplasticity and Pain (CNAP), Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.
²² Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, Scotland, United Kingdom.
²³ Pain Research and Intervention Center of Excellence, University of Florida, Gainesville, FL, United States.
²⁴ Department of Community Dentistry and Behavioral Sciences, College of Dentistry, University of Florida, Gainesville, FL, United States.
²⁵ Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, United States.
²⁶ Institute of Translational Psychiatry, University of Münster, Münster, Germany.
²⁷ Neurophysiopathology Unit, DiBrain Department, Bari Aldo Moro University, Bari, Italy.
²⁸ Department of Clinical and Health Psychology, Autonomous University of Barcelona, Barcelona, Spain.
²⁹ Functional Imaging Unit, Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.
³⁰ Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, VIC, Australia.
³¹ Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
³² Northern Sydney Local Health District, Sydney, NSW, Australia.
³³ The Kolling Institute, St Leonards, NSW, Australia.
³⁴ Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States.
³⁵ Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
³⁶ Neuro-Dol, Inserm, University Hospital of Clermont-Ferrand, University of Clermont-Auvergne, Clermont-Ferrand, France.
³⁷ NEUROPAIN Team, CRNL, CNRS, Inserm, University of Saint-Etienne, Saint-Etienne, France.
³⁸ Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
³⁹ Centre for Wellbeing, Resilience and Recovery, Neuroscience Research Australia, Randwick, NSW, Australia.
⁴⁰ Black Dog Institute, Randwick, NSW, Australia.
⁴¹ Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.
⁴² Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
⁴³ Department of Orthopaedics and Hand Surgery, Uppsala University Hospital, Uppsala, Sweden.
⁴⁴ Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
⁴⁵ Center for Addiction Medicine, Massachusetts General Hospital, Boston, MA, United States.
⁴⁶ Department of Radiology, University of Miami, Miller School of Medicine, Miami, FL, United States.
⁴⁷ Consortium Against Pain Inequality, University of Dundee, Dundee, Scotland, United Kingdom.
⁴⁸ Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig-Holstein, Kiel University, Kiel, Germany.
⁴⁹ CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
⁵⁰ Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
⁵¹ Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
⁵² Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
⁵³ Department of Biostatistics, Johns Hopkins University, Baltimore, MD, United States.
⁵⁴ Department of Anesthesia, Clinical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
⁵⁵ Department of Anesthesiology, Center for Translational Pain Medicine, Duke University School of Medicine, Durham, NC, United States.
⁵⁶ Department of Biology, Morgan State University, Baltimore, MD, United States.
⁵⁷ Institute for Translational Neuroscience, University of Münster, Münster, Germany.
⁵⁸ Department of Rehabilitation Sciences, Ghent University, Ghent, Belgium.
⁵⁹ Department of Neurology, Center for Interdisciplinary Pain Medicine and TUM-Neuroimaging Center, School of Medicine and Health, Technical University of Munich, Munich, Germany.
⁶⁰ The Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, United States.
⁶¹ Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.
⁶² Department of Neurology, University Hospital Greifswald, Greifswald, Germany.
⁶³ Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, United States.
⁶⁴ Atlanta Veterans Affairs Healthcare System, Atlanta, GA, United States.
⁶⁵ Department of Psychiatry, School of Medicine, Duke University, Durham, NC, United States.
⁶⁶ Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, QC, Canada.
⁶⁷ Department of Anesthesia, Faculty of Medicine, McGill University, Montreal, QC, Canada.
⁶⁸ Alan Edwards Centre for Research on Pain (AECRP), McGill University, Montreal, QC, Canada.
⁶⁹ School of Psychology, Trinity College Dublin, Dublin, Ireland.
⁷⁰ Trinity Institute for Neuroscience, Trinity College Dublin, Dublin, Ireland.
⁷¹ Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.
⁷² Developmental Neurosciences Department, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
⁷³ Department of Anaesthesia and Pain Medicine, Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom.
⁷⁴ Dartmouth College, Hanover, NH, United States.
⁷⁵ Division of Pain Medicine, Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA, United States.
⁷⁶ Center for Pain Medicine, Department of Anesthesiology, University of California San Diego, La Jolla, CA, United States.

PMID: 39058957
PMCID: PMC11562752
DOI: 10.1097/j.pain.0000000000003317

ENIGMA-Chronic Pain: a worldwide initiative to identify brain correlates of chronic pain

Yann Quidé et al. Pain. 2024.

. 2024 Dec 1;165(12):2662-2666.

doi: 10.1097/j.pain.0000000000003317. Epub 2024 Jul 26.

Authors

Affiliations

¹ School of Psychology, The University of New South Wales (UNSW) Sydney, Sydney, NSW, Australia.
² Centre for Pain IMPACT, Neuroscience Research Australia, Randwick, NSW, Australia.
³ Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
⁴ Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
⁵ Division of Population Health and Genomics, Medical Research Institute, University of Dundee, Dundee, Scotland, United Kingdom.
⁶ Center for Translational Pain Research, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
⁷ Department of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
⁸ Department of Anesthesiology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
⁹ Department of General Internal Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
¹⁰ Department of Psychiatry and Behavioral Sciences, Neuro-X Lab, Medical University of South Carolina, Charleston, SC, United States.
¹¹ Duke-UNC Brain Imaging and Analysis Center, Duke University, Durham, NC, United States.
¹² VA Mid-Atlantic MIRECC, Durham VA Medical Center, Durham VA, Durham, NC, United States.
¹³ Department of Paediatrics, University of Oxford, Oxford, United Kingdom.
¹⁴ Department of Psychiatry, University of California, San Diego, CA, United States.
¹⁵ Center for Behavior Genetics of Aging, University of California, San Diego, CA, United States.
¹⁶ MRI Research Unit, Department of Radiology, Hospital del Mar, Barcelona, Spain.
¹⁷ IsGlobal, Barcelona, Spain.
¹⁸ Medical University of South Carolina, Charleston, SC, United States.
¹⁹ Ralph H. Johnson VAMC, Charleston, SC, United States.
²⁰ Neuroscience Graduate Program, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, Canada.
²¹ Center for Neuroplasticity and Pain (CNAP), Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.
²² Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, Scotland, United Kingdom.
²³ Pain Research and Intervention Center of Excellence, University of Florida, Gainesville, FL, United States.
²⁴ Department of Community Dentistry and Behavioral Sciences, College of Dentistry, University of Florida, Gainesville, FL, United States.
²⁵ Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, United States.
²⁶ Institute of Translational Psychiatry, University of Münster, Münster, Germany.
²⁷ Neurophysiopathology Unit, DiBrain Department, Bari Aldo Moro University, Bari, Italy.
²⁸ Department of Clinical and Health Psychology, Autonomous University of Barcelona, Barcelona, Spain.
²⁹ Functional Imaging Unit, Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.
³⁰ Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, VIC, Australia.
³¹ Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
³² Northern Sydney Local Health District, Sydney, NSW, Australia.
³³ The Kolling Institute, St Leonards, NSW, Australia.
³⁴ Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States.
³⁵ Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
³⁶ Neuro-Dol, Inserm, University Hospital of Clermont-Ferrand, University of Clermont-Auvergne, Clermont-Ferrand, France.
³⁷ NEUROPAIN Team, CRNL, CNRS, Inserm, University of Saint-Etienne, Saint-Etienne, France.
³⁸ Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
³⁹ Centre for Wellbeing, Resilience and Recovery, Neuroscience Research Australia, Randwick, NSW, Australia.
⁴⁰ Black Dog Institute, Randwick, NSW, Australia.
⁴¹ Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.
⁴² Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
⁴³ Department of Orthopaedics and Hand Surgery, Uppsala University Hospital, Uppsala, Sweden.
⁴⁴ Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
⁴⁵ Center for Addiction Medicine, Massachusetts General Hospital, Boston, MA, United States.
⁴⁶ Department of Radiology, University of Miami, Miller School of Medicine, Miami, FL, United States.
⁴⁷ Consortium Against Pain Inequality, University of Dundee, Dundee, Scotland, United Kingdom.
⁴⁸ Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig-Holstein, Kiel University, Kiel, Germany.
⁴⁹ CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
⁵⁰ Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
⁵¹ Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
⁵² Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
⁵³ Department of Biostatistics, Johns Hopkins University, Baltimore, MD, United States.
⁵⁴ Department of Anesthesia, Clinical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
⁵⁵ Department of Anesthesiology, Center for Translational Pain Medicine, Duke University School of Medicine, Durham, NC, United States.
⁵⁶ Department of Biology, Morgan State University, Baltimore, MD, United States.
⁵⁷ Institute for Translational Neuroscience, University of Münster, Münster, Germany.
⁵⁸ Department of Rehabilitation Sciences, Ghent University, Ghent, Belgium.
⁵⁹ Department of Neurology, Center for Interdisciplinary Pain Medicine and TUM-Neuroimaging Center, School of Medicine and Health, Technical University of Munich, Munich, Germany.
⁶⁰ The Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, United States.
⁶¹ Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.
⁶² Department of Neurology, University Hospital Greifswald, Greifswald, Germany.
⁶³ Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, United States.
⁶⁴ Atlanta Veterans Affairs Healthcare System, Atlanta, GA, United States.
⁶⁵ Department of Psychiatry, School of Medicine, Duke University, Durham, NC, United States.
⁶⁶ Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, QC, Canada.
⁶⁷ Department of Anesthesia, Faculty of Medicine, McGill University, Montreal, QC, Canada.
⁶⁸ Alan Edwards Centre for Research on Pain (AECRP), McGill University, Montreal, QC, Canada.
⁶⁹ School of Psychology, Trinity College Dublin, Dublin, Ireland.
⁷⁰ Trinity Institute for Neuroscience, Trinity College Dublin, Dublin, Ireland.
⁷¹ Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.
⁷² Developmental Neurosciences Department, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
⁷³ Department of Anaesthesia and Pain Medicine, Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom.
⁷⁴ Dartmouth College, Hanover, NH, United States.
⁷⁵ Division of Pain Medicine, Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA, United States.
⁷⁶ Center for Pain Medicine, Department of Anesthesiology, University of California San Diego, La Jolla, CA, United States.

PMID: 39058957
PMCID: PMC11562752
DOI: 10.1097/j.pain.0000000000003317

No abstract available

PubMed Disclaimer

Conflict of interest statement

None of the authors declare any conflicts of interest. The views expressed in this article are those of the authors and do not necessarily reflect the position or policy of the Department of Veterans Affairs or the United States government, or those of the NHS, the NIHR, or the Department of Health from the United Kingdom.

Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article.

References

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1. Bas-Hoogendam JM, Groenewold NA, Aghajani M, Freitag GF, Harrewijn A, Hilbert K, Jahanshad N, Thomopoulos SI, Thompson PM, Veltman DJ, Winkler AM, Lueken U, Pine DS, van der Wee NJA, Stein DJ; ENIGMA-Anxiety Working Group. ENIGMA-anxiety working group: rationale for and organization of large-scale neuroimaging studies of anxiety disorders. Hum Brain Mapp 2022;43:83–112. - PMC - PubMed
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ENIGMA-Chronic Pain: a worldwide initiative to identify brain correlates of chronic pain

Affiliations

ENIGMA-Chronic Pain: a worldwide initiative to identify brain correlates of chronic pain

Authors

Affiliations

Conflict of interest statement

References

Grants and funding

LinkOut - more resources

Full Text Sources

Miscellaneous