A metabolic balance of GLP-1 and NMDA receptors in the brain

Jessica T Y Yue¹, Ameth N Garrido², Tony K T Lam³

Affiliations

¹ Department of Physiology, Alberta Diabetes Institute, Neuroscience and Mental Health Institute, and Group on Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, AB, Canada.
² Toronto General Hospital Research Institute, UHN, Toronto, ON, Canada; Department of Physiology, University of Toronto, Toronto, ON, Canada.
³ Toronto General Hospital Research Institute, UHN, Toronto, ON, Canada; Department of Physiology, University of Toronto, Toronto, ON, Canada; Department of Medicine, University of Toronto, Toronto, ON, Canada; Banting and Best Diabetes Centre, University of Toronto, Toronto, ON, Canada. Electronic address: tonykt.lam@uhn.ca.

PMID: 39059361
DOI: 10.1016/j.cell.2024.06.031

Free article

A metabolic balance of GLP-1 and NMDA receptors in the brain

Jessica T Y Yue et al. Cell. 2024.

Free article

. 2024 Jul 25;187(15):3854-3856.

doi: 10.1016/j.cell.2024.06.031.

Authors

Jessica T Y Yue¹, Ameth N Garrido², Tony K T Lam³

Affiliations

¹ Department of Physiology, Alberta Diabetes Institute, Neuroscience and Mental Health Institute, and Group on Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, AB, Canada.
² Toronto General Hospital Research Institute, UHN, Toronto, ON, Canada; Department of Physiology, University of Toronto, Toronto, ON, Canada.
³ Toronto General Hospital Research Institute, UHN, Toronto, ON, Canada; Department of Physiology, University of Toronto, Toronto, ON, Canada; Department of Medicine, University of Toronto, Toronto, ON, Canada; Banting and Best Diabetes Centre, University of Toronto, Toronto, ON, Canada. Electronic address: tonykt.lam@uhn.ca.

PMID: 39059361
DOI: 10.1016/j.cell.2024.06.031

Abstract

Glucagon-like peptide-1 (GLP-1) and N-methyl-D-aspartate (NMDA) receptors in the brain regulate metabolic homeostasis. In a paper published in Nature, Petersen et al. describe a bimodal molecule that conjugates a GLP-1 analog with MK-801 (NMDA receptor antagonist), which lowers feeding and body weight to a greater extent than the GLP-1R agonist alone.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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A metabolic balance of GLP-1 and NMDA receptors in the brain

Affiliations

A metabolic balance of GLP-1 and NMDA receptors in the brain

Authors

Affiliations

Abstract

Conflict of interest statement

MeSH terms

Substances

LinkOut - more resources

Full Text Sources