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Comment
. 2024 Jul 25;84(14):2596-2597.
doi: 10.1016/j.molcel.2024.06.034.

STING: Stay near to STIM(1) neuroprotection

Hong-Gyun Lee  1 , Francisco J Quintana  2
Affiliations
Free article
Comment

STING: Stay near to STIM(1) neuroprotection

Hong-Gyun Lee et al. Mol Cell. .
Free article

Abstract

In a recent publication in Cell, Woo et al.1 report that stimulator of interferon genes (STING) links inflammation with glutamate-driven excitotoxicity to induce ferroptosis, identifying a mechanism of inflammation-induced neurodegeneration and also a novel candidate therapeutic target for multiple sclerosis.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • STING orchestrates the neuronal inflammatory stress response in multiple sclerosis.
    Woo MS, Mayer C, Binkle-Ladisch L, Sonner JK, Rosenkranz SC, Shaposhnykov A, Rothammer N, Tsvilovskyy V, Lorenz SM, Raich L, Bal LC, Vieira V, Wagner I, Bauer S, Glatzel M, Conrad M, Merkler D, Freichel M, Friese MA. Woo MS, et al. Cell. 2024 Jul 25;187(15):4043-4060.e30. doi: 10.1016/j.cell.2024.05.031. Epub 2024 Jun 14. Cell. 2024. PMID: 38878778

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