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Review
. 2024 Aug 12;42(8):1319-1325.
doi: 10.1016/j.ccell.2024.07.002. Epub 2024 Jul 25.

CAR T cell combination therapies to treat cancer

Ugur Uslu  1 , Sofia Castelli  1 , Carl H June  2
Affiliations
Free article
Review

CAR T cell combination therapies to treat cancer

Ugur Uslu et al. Cancer Cell. .
Free article

Abstract

Chimeric antigen receptor (CAR) T cells are effectively used in certain hematological malignancies, though tumor relapse and limited success in solid tumors persist. Recent efforts focus on developing combination treatments to enhance outcomes and safety. Here, we provide a comprehensive overview of such combinatorial approaches and a consideration of ongoing clinical trials.

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Conflict of interest statement

Declaration of interests C.H.J. is an inventor on patents and/or patent applications licensed to Novartis Institutes of Biomedical Research and receives license revenue from such licenses. C.H.J. is an inventor on patents and/or patent applications licensed to Kite Pharma, Capstan Therapeutics, Dispatch Therapeutics, and BlueWhale Bio. C.H.J. is a member of the scientific advisory boards of AC Immune, BluesphereBio, BlueWhale Bio, Cabaletta, Carisma, Cartography, Cellares, Celldex, Decheng, Poseida, Replay Bio, Verismo, ViTToria, and WIRB-Copernicus.

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