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Case Reports
. 2024 Oct:131-132:110802.
doi: 10.1016/j.clinbiochem.2024.110802. Epub 2024 Jul 24.

Long term false positive hsTnI on Alinity I probably caused by macrotroponin complex: Case report

Tamara Sušić  1 , Marijana Miler  2 , Nora Nikolac Gabaj  3 , Andrea Tešija Kuna  4 , Krešimir Kordić  5 , Vedrana Ilić  6 , Ozren Vinter  5
Affiliations
Case Reports

Long term false positive hsTnI on Alinity I probably caused by macrotroponin complex: Case report

Tamara Sušić et al. Clin Biochem. 2024 Oct.

Abstract

Elevated troponin levels are often indicative of various cardiac diseases; however, analytical interference can lead to false positive troponin concentrations. We present the case of a 48-year-old female patient with persistently falsely elevated high sensitivity troponin I (hsTnI) probably caused by the presence of macrotroponin. Laboratory testing included determination of hsTnI using various analytical methods, serial dilutions and determination of heterophilic antibodies and other autoimmune antibodies. Only precipitation with polyethylene glycol (PEG) indicated the presence of an interference by causing a significant decrease in hsTnI concentration. Our results suggest that the falsely elevated hsTnI concentration could be due to interference with the macrotroponin complex.

Keywords: High sensitivity troponin I; Interferences; Macrotroponin; Myocarditis.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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