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Review
. 2024 Jul;42(4):463-469.
doi: 10.1007/s00774-024-01528-0. Epub 2024 Jul 26.

Crosstalk between kidney and bone: insights from CKD-MBD

Kodai Suzuki  1   2 , Keisuke Soeda  1 , Hirotaka Komaba  3   4
Affiliations
Review

Crosstalk between kidney and bone: insights from CKD-MBD

Kodai Suzuki et al. J Bone Miner Metab. 2024 Jul.

Abstract

The kidneys play an important role in the regulation of phosphate and calcium balance and serum concentrations, coordinated by fibroblast growth factor 23 (FGF23), parathyroid hormone (PTH), and 1,25-dihydroxyvitamin D (1,25D). In patients with chronic kidney disease (CKD), this regulation is impaired, leading to CKD-mineral and bone disorder (CKD-MBD), characterized by decreased 1,25D, elevated FGF23, secondary hyperparathyroidism, hyperphosphatemia, bone abnormalities, and vascular and soft-tissue calcification. While bone abnormalities associated with CKD-MBD, known as renal osteodystrophy, have been recognized as the most typical interaction between the kidney and bone, a number of other kidney-bone interactions have been identified, for which our knowledge of the pathogenesis of CKD-MBD has played an important role. This article summarizes recent findings on CKD-MBD and explores the crosstalk between the kidney and bone from the perspective of CKD-MBD.

Keywords: Bone; Chronic kidney disease; Fibroblast growth factor 23; Parathyroid hormone.

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