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Review
. 2024:1449:175-186.
doi: 10.1007/978-3-031-58572-2_11.

Clostridioides difficile Infections: Prevention and Treatment Strategies

Elvira Ingrid Levy  1 , Meltem Dinleyici  2 , Ener Dinleyici  3 , Yvan Vandenplas  4
Affiliations
Review

Clostridioides difficile Infections: Prevention and Treatment Strategies

Elvira Ingrid Levy et al. Adv Exp Med Biol. 2024.

Abstract

Clostridioides difficile is the most common causative agent of antibiotic-associated diarrhea. This spore forming, obligate anaerobic, gram-positive bacillus is becoming responsible for an increasing number of infections worldwide, both in community and in hospital settings, whose severity can vary widely from an asymptomatic infection to a lethal disease. While discontinuation of antimicrobial agents and antibiotic treatment of the infection remain the cornerstone of therapy, more recent fecal microbiota transplantation has also been valid as a therapy. The use of probiotics, especially Saccharomyces boulardii CNCM I-745 have become valid forms of prevention therapy. Although there are studies in adults with microbiota-targeted new generation therapies and Clostridium difficile vaccines, there are no data in the paediatric age group yet.

Keywords: Children; Clostridioides (Clostridium) difficile; Prevention; Probiotics; Recurrence; Treatment; Yeast.

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