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Review
. 2024 Jul 18;16(14):2579.
doi: 10.3390/cancers16142579.

SerpinB3: A Multifaceted Player in Health and Disease-Review and Future Perspectives

Silvia Cagnin  1 , Patrizia Pontisso  1 , Andrea Martini  1
Affiliations
Review

SerpinB3: A Multifaceted Player in Health and Disease-Review and Future Perspectives

Silvia Cagnin et al. Cancers (Basel). .

Abstract

SerpinB3, a member of the serine-protease inhibitor family, has emerged as a crucial player in various physiological and pathological processes. Initially identified as an oncogenic factor in squamous cell carcinomas, SerpinB3's intricate involvement extends from fibrosis progression and cancer to cell protection in acute oxidative stress conditions. This review explores the multifaceted roles of SerpinB3, focusing on its implications in fibrosis, metabolic syndrome, carcinogenesis and immune system impairment. Furthermore, its involvement in tissue protection from oxidative stress and wound healing underscores its potential as diagnostic and therapeutic tool. Recent studies have described the therapeutic potential of targeting SerpinB3 through its upstream regulators, offering novel strategies for cancer treatment development. Overall, this review underscores the importance of further research to fully elucidate the mechanisms of action of SerpinB3 and to exploit its therapeutic potential across various medical conditions.

Keywords: SerpinB3; biomarker; fibrosis; metabolism; oncology; protection from oxidative stress.

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Conflict of interest statement

The authors declare that P.P. and M.A. are listed as inventors of patent N. IT 102017000026858, European patent EP 392351 and P.P. of the Italian Patent Application N. 102022000014593 filed by the University of Padova, PTC pending. No conflicts of interest exist for S.C.

Figures

Figure 1
Figure 1
The multifaceted roles of SerpinB3. Graphical representation of the different biological activities of SerpinB3, mainly resulting in cell death protection, fibrosis, carcinogenesis and immune modulation. Created with BioRender.com.
Figure 2
Figure 2
The multiple roles of SerpinB3 in carcinogenesis. SerpinB3 can contribute to the progression of chronic liver disease and cancer development via the release of inflammatory, angiogenetic and pro-fibrogenic mediators. The activation of several intracellular pathways unravels the particular aggressiveness of tumors that express this serpin. Created with BioRender.com.
Figure 3
Figure 3
Protective roles of SerpinB3. Graphical representation of the positive effect of SerpinB3 in acute stress conditions and in autoimmune settings. SLE, systemic lupus erythematosus. Created with BioRender.com.
See this image and copyright information in PMC

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