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Review
. 2024 Jul 18;13(7):669.
doi: 10.3390/antibiotics13070669.

Arcobacteraceae: An Exploration of Antibiotic Resistance Featuring the Latest Research Updates

Davide Buzzanca  1 , Elisabetta Chiarini  1 , Valentina Alessandria  1
Affiliations
Review

Arcobacteraceae: An Exploration of Antibiotic Resistance Featuring the Latest Research Updates

Davide Buzzanca et al. Antibiotics (Basel). .

Abstract

The Arcobacteraceae bacterial family includes species isolated from animals and related food products. Moreover, these species have been found in other ecological niches, including water. Some species, particularly Arcobacter butzleri and Arcobacter cryaerophilus, have been isolated from human clinical cases and linked to gastrointestinal symptoms. The presence of antibiotic-resistant strains is a concern for public health, considering the possible zoonoses and foodborne infections caused by contaminated food containing bacteria resistant to antibiotic treatments. This review aims to highlight the importance of antibiotic resistance in Arcobacter spp. isolates from several sources, including information about antibiotic classes to which this bacterium has shown resistance. Arcobacter spp. demonstrated a wide spectrum of antibiotic resistance, including several antibiotic resistance genes. Antibiotic resistance genomic traits include efflux pumps and mutations in antibiotic target proteins. The literature shows a high proportion of Arcobacter spp. that are multidrug-resistant. However, studies in the literature have primarily focused on the evaluation of antibiotic resistance in A. butzleri and A. cryaerophilus, as these species are frequently isolated from various sources. These aspects underline the necessity of studies focused on several Arcobacter species that could potentially be isolated from several sources.

Keywords: Arcobacter spp.; antimicrobial resistance; food safety; foodborne pathogen; multiple drug resistance; zoonosis.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
AMR mechanisms in Arcobacter spp. The figure shows genomic traits at which Arcobacter spp. resulted in antibiotic resistance or that were detected through molecular methods. Antibiotics/classes and related mechanisms of action are included in the red and green boxes. The protein figures were uploaded from Uniprot (https://www.uniprot.org/; accessed on 7 June 2024) [57].
See this image and copyright information in PMC

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