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Review
. 2024 Jul 15;14(14):1522.
doi: 10.3390/diagnostics14141522.

Line-Field Confocal Optical Coherence Tomography for the Diagnosis of Skin Tumors: A Systematic Review and Meta-Analysis

Shazli Razi  1   2 , Yen-Hong Kuo  3   4 , Gaurav Pathak  5 , Priya Agarwal  5 , Arianna Horgan  5 , Prachi Parikh  5 , Farah Deshmukh  2 , Babar K Rao  5   6   7
Affiliations
Review

Line-Field Confocal Optical Coherence Tomography for the Diagnosis of Skin Tumors: A Systematic Review and Meta-Analysis

Shazli Razi et al. Diagnostics (Basel). .

Abstract

A line-field confocal optical coherence tomography (LC-OCT) combines confocal microscopy and optical coherence tomography into a single, rapid, easy-to-use device. This meta-analysis was performed to determine the reliability of LC-OCT for diagnosing malignant skin tumors. PubMed, EMBASE, Web of Science databases, and the Cochrane Library were searched for research studies in the English language from inception till December 2023. To assess quality and the risk of bias, the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) was used. The sensitivity and specificity of each study were calculated. The bivariate summary sensitivity and specificity were calculated using the linear mixed model. Five studies with 904 reported per lesion analyses in our study; the specificity and sensitivity ranged from 67% to 97% and 72% to 92%, respectively. The pooled specificity and sensitivity were 91% (95% CI: 76-97%) and 86.9% (95% CI: 81.8-90.8%), respectively. The summary sensitivity and specificity from the bivariate approach are 86.9% (95% CI: 81.8-90.8%) and 91.1% (95% CI: 76.7-97.0%), respectively. The area under the curve is 0.914. LC-OCT shows great sensitivity and specificity in diagnosing malignant skin tumors. However, due to the limited number of studies included in our meta-analysis, it is premature to elucidate the true potential of LC-OCT.

Keywords: basal cell carcinoma; line-field confocal optical coherence tomography; melanoma; squamous cell carcinoma.

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Conflict of interest statement

Babar Rao is a consultant for Caliber ID (The manufacturer of VivaScope®). The other authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
(A) Vertical view of LC-OCT (B) Horizontal or Enface view of LC-OCT. (C) Dermoscopic view of the lesion.
Figure 2
Figure 2
Flow diagram of study selection.
Figure 3
Figure 3
(A) Forest plot of pooled sensitivity. (B) Forest plot of pooled specificity (TP = true positive, FP = false positive, FN = false negative, TN = true negative) [2,12,13,14,15].
Figure 4
Figure 4
Summary Receiver Operating Characteristic (SROC) Curve for Evaluating the Sensitivity and Specificity.
See this image and copyright information in PMC

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