Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jul 10;12(7):1532.
doi: 10.3390/biomedicines12071532.

Predictive Value and Diagnostic Potential of IL-10, IL-17A, IL1-β, IL-6, CXCL, and MCP for Severe COVID-19 and COVID-19 Mortality

Roxana-Elena Cîrjaliu  1 , Ioan-Tiberiu Tofolean  1 , Doina-Ecaterina Tofolean  1 , Anca Chisoi  2 , Cristian Oancea  3 , Emanuela Vastag  3 , Monica Marc  3 , Felix Bratosin  4 , Ovidiu Rosca  4 , Ariadna-Petronela Fildan  1
Affiliations

Predictive Value and Diagnostic Potential of IL-10, IL-17A, IL1-β, IL-6, CXCL, and MCP for Severe COVID-19 and COVID-19 Mortality

Roxana-Elena Cîrjaliu et al. Biomedicines. .

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) necessitates advanced prognostic tools to anticipate disease progression and optimize patient outcomes. This study evaluates the predictive value and diagnostic potential of interleukins interleukin (IL) IL-10, IL-17A, IL1-β, IL-6, chemokine ligand (CXCL), and Monocyte Chemotactic Protein (MCP) for severe coronavirus disease 2019 (COVID-19) and COVID-19 mortality, aiming to correlate cytokine levels with disease severity. Conducted from January 2023 to January 2024, this prospective cohort study involved patients hospitalized with moderate and severe COVID-19 from Romania. This study analyzed statistically significant predictors of severe COVID-19 outcomes. IL-6 and MCP emerged as significant, with hazard ratios (HRs) of 2.35 (95% confidence interval (CI): 1.54-3.59, p = 0.014) and 2.05 (95% CI: 1.22-3.45, p = 0.007), respectively. Compound scores integrating multiple inflammatory markers also demonstrated predictive value; Compound Score 2 had an HR of 2.23 (95% CI: 1.35-3.68, p = 0.002), surpassing most single markers in association with severe disease. Notably, interleukins IL-10 and IL-1β did not show significant associations with disease severity. This study underscores the importance of IL-6 and MCP as robust predictors of severe COVID-19, substantiating their role in clinical assessments to foresee patient deterioration. The utility of compound scores in enhancing predictive accuracy suggests a composite approach may be more effective in clinical settings.

Keywords: COVID-19; SARS-CoV-2; inflammation; respiratory infections.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
ROC curve analysis for severe COVID-19 predictors based on inflammatory scores; CXCL—chemokine Ligand; IL—interleukin; MCP—monocyte chemotactic protein; AUC—area under curve.
Figure 2
Figure 2
Forest plot of severe COVID-19 predictors based on inflammatory scores.
See this image and copyright information in PMC

References

    1. Sawicka B., Aslan I., Della Corte V., Periasamy A., Krishnamurthy S.K., Mohammed A., Tolba Said M.M., Saravanan P., Del Gaudio G., Adom D., et al. Coronavirus Drug Discovery: SARS-CoV-2 (COVID-19) Prevention, Diagnosis, and Treatment. Volume 1 in Drug Discovery Update. Elsevier; Amsterdam, The Netherlands: 2022. The coronavirus global pandemic and its impacts on society; pp. 267–311. - DOI
    1. Del Re D., Palla L., Meridiani P., Soffi L., Loiudice M.T., Antinozzi M., Cattaruzza M.S. The spread in time and space of COVID-19 pandemic waves: The Italian experience from mortality data analyses. Front. Public Health. 2024;12:1324033. doi: 10.3389/fpubh.2024.1324033. - DOI - PMC - PubMed
    1. Padilla-Bórquez D.L., Matuz-Flores M.G., Hernández-Bello J., Sánchez-Zuno G.A., García-Arellano S., Oregon-Romero E., Herrera-Godina M.G., González-Estevez G., Adan-Bante N.P., Rosas-Rodríguez J.A., et al. Seroprevalence of IgM/IgG and Neutralizing Antibodies against SARS-CoV-2 in Unvaccinated Young Adults from Mexico Who Reported Not Having Had a Previous COVID-19 Infection. Can. J. Infect. Dis. Med. Microbiol. 2024;2024:8871439. doi: 10.1155/2024/8871439. - DOI - PMC - PubMed
    1. Çelik I., Öztürk R. From asymptomatic to critical illness: Decoding various clinical stages of COVID-19. Turk. J. Med. Sci. 2021;51:3284–3300. doi: 10.3906/sag-2107-13. - DOI - PMC - PubMed
    1. Marks M., O’Hara G., Houlihan C., Bell L., Heightman M., Hart N. Encyclopedia of Respiratory Medicine. 2nd ed. Academic Press; Cambridge, MA, USA: 2022. Severe Acute Respiratory Syndrome Coronavirus 2; pp. 231–242. - DOI

LinkOut - more resources