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Review
. 2024 Jul 12;12(7):1554.
doi: 10.3390/biomedicines12071554.

How General and Inflammatory Status Impacts on the Prognosis of Patients Affected by Lung Cancer: State of the Art

Antonio Mazzella  1 , Riccardo Orlandi  1 , Sebastiano Maiorca  1 , Clarissa Uslenghi  1 , Matteo Chiari  1 , Luca Bertolaccini  1 , Monica Casiraghi  1 , Giorgio Lo Iacono  1 , Lara Girelli  1 , Lorenzo Spaggiari  1   2
Affiliations
Review

How General and Inflammatory Status Impacts on the Prognosis of Patients Affected by Lung Cancer: State of the Art

Antonio Mazzella et al. Biomedicines. .

Abstract

Pulmonary cancer is often associated with systemic inflammation and poor nutritional status and these two aspects are strongly correlated and related to the scarce infiltration of a tumor by immune cells. We reviewed all English literature reviews from 2000 to 2024 from PubMed, Scopus and Google Scholar, including original articles, review articles, and metanalyses. We excluded non-English language articles and case reports/case series. Generally speaking, nutritional and inflammatory status largely affect medium and long-term prognosis in lung cancer patients. A correct stratification of patients could improve their preoperative general functional nutritional and inflammatory status, minimizing, therefore, possible treatment complications and improving long-term prognosis.

Keywords: NSCLC; general status; inflammation; inflammatory status; lung cancer; metabolic status; metabolism; prognosis.

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Conflict of interest statement

The authors declare no conflicts of interest.

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