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. 2024 Jul 9;13(14):3992.
doi: 10.3390/jcm13143992.

Blood-Count-Derived Inflammatory Markers as Predictors of Response to Biologics and Small-Molecule Inhibitors in Psoriasis: A Multicenter Study

Silviu-Horia Morariu  1 , Ovidiu Simion Cotoi  2 , Oana Mirela Tiucă  1 , Adrian Baican  3 , Laura Gheucă-Solovăstru  4 , Hana Decean  5 , Ilarie Brihan  6 , Katalin Silaghi  7 , Viorica Biro  8 , Diana Șerban-Pescar  9 , Ioana Măgureanu  10 , Mircea Ambros  10 , Roxana Ioana Ilcuș  10 , Lavinia Prodan  7 , Andreea Beatrix Bălan  10 , Mădălina Husariu  10 , Dumitrita Lenuta Gugulus  5 , Radu Alexandru Stan  10 , Vlad Voiculescu  11 , Alin Codruț Nicolescu  12
Affiliations

Blood-Count-Derived Inflammatory Markers as Predictors of Response to Biologics and Small-Molecule Inhibitors in Psoriasis: A Multicenter Study

Silviu-Horia Morariu et al. J Clin Med. .

Abstract

Background: Psoriasis is an immune-mediated chronic disorder associated with various comorbidities. Even though biologics and small-molecule inhibitors are the mainstay treatment for moderate-to-severe psoriasis, there is no current consensus regarding which agent should be used for a specific type of patient. This paper aims to test the reliability of blood-count-derived inflammatory markers in assessing treatment response to biologics and small-molecule inhibitors in psoriasis. Material and Methods: Bio-naïve adult patients diagnosed with chronic plaque psoriasis fulfilling the inclusion criteria were enrolled. They were divided into study subgroups based on treatment of choice, and blood-count-derived inflammatory markers were analyzed at baseline, three-month, six-month, and at twelve-month visits. Results: A total of 240 patients were included. The highest number of patients underwent treatment with ixekizumab. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), platelet-to-monocyte ratio (PMR), monocyte-to-lymphocyte ratio (MLR), derived neutrophil-to-lymphocyte ratio (d-NLR), systemic inflammation response index (SIRI), systemic immune inflammation index (SII), and aggregate index of systemic inflammation (AISI) all varied significantly (p < 0.005) between the four visits. The psoriasis area severity index (PASI) score correlated with PLR, d-NLR, and SII, while the psoriasis scalp severity index (PSSI) score correlated with AISI and SIRI. More than half of patients reached the target goal of PASI90 at the six-month visit. A total of 77 patients were super-responders, with the highest number undergoing treatment with ixekizumab. Higher baseline values of d-NLR and SIRI are independent predictors of the super-responder status. Conclusions: Blood-count-derived inflammatory markers can serve as indicators of treatment response to biologics in psoriasis, while d-NLR and SIRI were independent predictors of super-responders in our study.

Keywords: biologics; blood count; inflammation; noninvasive; psoriasis.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Percentage of patients reaching target goals based on the treatment of choice.
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References

    1. Yamazaki F. Psoriasis: Comorbidities. J. Dermatol. 2021;48:732–740. doi: 10.1111/1346-8138.15840. - DOI - PMC - PubMed
    1. Ruan Z., Lu T., Chen Y., Yuan M., Yu H., Liu R., Xie X. Association between Psoriasis and Nonalcoholic Fatty Liver Disease among Outpatient US Adults. JAMA Dermatol. 2022;158:745. doi: 10.1001/jamadermatol.2022.1609. - DOI - PMC - PubMed
    1. Mantovani A., Gisondi P., Lonardo A., Targher G. Relationship between Non-Alcoholic Fatty Liver Disease and Psoriasis: A Novel Hepato-Dermal Axis? Int. J. Mol. Sci. 2016;17:217. doi: 10.3390/ijms17020217. - DOI - PMC - PubMed
    1. Man M.-A., Davidescu L., Motoc N.-S., Rajnoveanu R.-M., Bondor C.-I., Pop C.-M., Toma C. Diagnostic Value of the Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) in Various Respiratory Diseases: A Retrospective Analysis. Diagnostics. 2021;12:81. doi: 10.3390/diagnostics12010081. - DOI - PMC - PubMed
    1. Misiewicz A., Dymicka-Piekarska V. Fashionable, but What is Their Real Clinical Usefulness? NLR, LMR, and PLR as a Promising Indicator in Colorectal Cancer Prognosis: A Systematic Review. J. Inflamm. Res. 2023;16:69–81. doi: 10.2147/JIR.S391932. - DOI - PMC - PubMed

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