Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Jul 9;13(14):3996.
doi: 10.3390/jcm13143996.

Endometriosis and Adenomyosis: Modern Concepts of Their Clinical Outcomes, Treatment, and Management

Jessica Ottolina  1 , Roberta Villanacci  1 , Sara D'Alessandro  1 , Xuemin He  2 , Giorgia Grisafi  1 , Stefano Maria Ferrari  1 , Massimo Candiani  1
Affiliations
Review

Endometriosis and Adenomyosis: Modern Concepts of Their Clinical Outcomes, Treatment, and Management

Jessica Ottolina et al. J Clin Med. .

Abstract

Endometriosis and adenomyosis are complex gynecological conditions characterized by diverse clinical presentations, including superficial peritoneal endometriosis (SPE), ovarian endometrioma (OMA), and deep infiltrating endometriosis (DIE). The hallmark features of these pathologies involve the manifestation of pain symptoms and infertility, and approximately 30% of patients are asymptomatic. Despite ongoing research, definitive treatments for these conditions remain elusive, and clinical management primarily revolves around medical or surgical interventions. Recent advancements in our understanding of the efficacy of various treatment modalities, including medical therapy and surgical interventions, have provided clinicians with valuable insights into pain relief and fertility preservation. This review aims to provide an updated overview of the latest literature on clinical outcomes, treatment options, and management strategies for different types of endometriosis. By synthesizing the newest available data, this review seeks to inform clinicians and guide decision making based on factors such as patients' symptom severity, childbearing desire, and overall health.

Keywords: adenomyosis; deep infiltrating endometriosis; endometriosis; ovarian endometriosis; superficial peritoneal endometriosis.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
PRISMA flow diagram of the article selection process.
See this image and copyright information in PMC

References

    1. Becker C.M., Bokor A., Heikinheimo O., Horne A., Jansen F., Kiesel L., King K., Kvaskoff M., Nap A., Petersen K., et al. ESHRE Guidelines: Endometriosis. Hum. Reprod. Open. 2022;2022:hoac009. doi: 10.1093/hropen/hoac009. - DOI - PMC - PubMed
    1. Koninckx P.R., Meuleman C., Demeyere S., Lesaffre E., Cornillie F.J. Suggestive evidence that pelvic endometriosis is a progressive disease, whereas deeply infiltrating endometriosis is associated with pelvic pain. Fertil. Steril. 1991;55:759–765. doi: 10.1016/S0015-0282(16)54244-7. - DOI - PubMed
    1. Saunders P.T.K., Horne A.W. Endometriosis: Etiology, pathobiology, and therapeutic prospects. Cell. 2021;184:2807–2824. doi: 10.1016/j.cell.2021.04.041. - DOI - PubMed
    1. Sanchez A.M., Viganò P., Somigliana E., Panina-Bordignon P., Vercellini P., Candiani M. The distinguishing cellular and molecular features of the endometriotic ovarian cyst: From pathophysiology to the potential endometrioma-mediated damage to the ovary. Hum. Reprod. Update. 2014;20:217–230. doi: 10.1093/humupd/dmt053. - DOI - PubMed
    1. Muzii L., Di Tucci C., Di Feliciantonio M., Galati G., Verrelli L., Di Donato V., Marchetti C., Panici P.B. Management of Endometriomas. Semin. Reprod. Med. 2017;35:25–30. doi: 10.1055/s-0036-1597126. - DOI - PubMed

LinkOut - more resources