Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jul 10;13(14):4038.
doi: 10.3390/jcm13144038.

Enhanced Diagnostic Precision: Assessing Tumor Differentiation in Head and Neck Squamous Cell Carcinoma Using Multi-Slice Spiral CT Texture Analysis

Lays Assolini Pinheiro de Oliveira  1   2 , Diana Lorena Garcia Lopes  2 , João Pedro Perez Gomes  3 , Rafael Vinicius da Silveira  4   5 , Daniel Vitor Aguiar Nozaki  6 , Lana Ferreira Santos  7 , Gabriela Castellano  4   5 , Sérgio Lúcio Pereira de Castro Lopes  7 , Andre Luiz Ferreira Costa  1   2   6
Affiliations

Enhanced Diagnostic Precision: Assessing Tumor Differentiation in Head and Neck Squamous Cell Carcinoma Using Multi-Slice Spiral CT Texture Analysis

Lays Assolini Pinheiro de Oliveira et al. J Clin Med. .

Abstract

This study explores the efficacy of texture analysis by using preoperative multi-slice spiral computed tomography (MSCT) to non-invasively determine the grade of cellular differentiation in head and neck squamous cell carcinoma (HNSCC). In a retrospective study, MSCT scans of patients with HNSCC were analyzed and classified based on its histological grade as moderately differentiated, well-differentiated, or poorly differentiated. The location of the tumor was categorized as either in the bone or in soft tissues. Segmentation of the lesion areas was conducted, followed by texture analysis. Eleven GLCM parameters across five different distances were calculated. Median values and correlations of texture parameters were examined in relation to tumor differentiation grade by using Spearman's correlation coefficient and Kruskal-Wallis and Dunn tests. Forty-six patients were included, predominantly female (87%), with a mean age of 66.7 years. Texture analysis revealed significant parameter correlations with histopathological grades of tumor differentiation. The study identified no significant age correlation with tumor differentiation, which underscores the potential of texture analysis as an age-independent biomarker. The strong correlations between texture parameters and histopathological grades support the integration of this technique into the clinical decision-making process.

Keywords: computed tomography; computer-assisted diagnosis; oral cancer; radiomics; tumor.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
(A) Axial MSCT image shows squamous cell carcinoma located in the tonsillar pillar on the left side. (B) 3D VOI (red) segmentation process covering the lesion.
Figure 2
Figure 2
The groups are statistically different at 5% significance level regarding parameters followed by asterisk (*). All parameters were rescaled to be inserted into the graph in order to avoid distorting the scale for the other parameters.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Panarese I., Aquino G., Ronchi A., Longo F., Montella M., Cozzolino I., Roccuzzo G., Colella G., Caraglia M., Franco R. Oral and Oropharyngeal squamous cell carcinoma: Prognostic and predictive parameters in the etiopathogenetic route. Expert Rev. Anticancer Ther. 2019;19:105–119. doi: 10.1080/14737140.2019.1561288. - DOI - PubMed
    1. Scully C., Bagan J. Oral squamous cell carcinoma: Overview of current understanding of aetiopathogenesis and clinical implications. Oral. Dis. 2009;15:388–399. doi: 10.1111/j.1601-0825.2009.01563.x. - DOI - PubMed
    1. Ribeiro C.V., Vasconcelos A.C., Andrade Filho Jde S. Apoptosis and expression of argyrophilic nucleolus organizer regions in epithelial neoplasms of the larynx. Braz. J. Otorhinolaryngol. 2015;81:158–166. doi: 10.1016/j.bjorl.2014.12.003. - DOI - PMC - PubMed
    1. Broders A.C. The microscopic grading of cancer. Surg. Clin. N. Am. 1941;21:947–962.
    1. Bryne M., Koppang H.S., Lilleng R., Stene T., Bang G., Dabelsteen E. New malignancy grading is a better prognostic indicator than Broders’ grading in oral squamous cell carcinomas. J. Oral. Pathol. Med. 1989;18:432–437. doi: 10.1111/j.1600-0714.1989.tb01339.x. - DOI - PubMed

LinkOut - more resources