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. 2024 Jul 11;13(14):4048.
doi: 10.3390/jcm13144048.

Results of Endometrial Biopsy and Its Impact on Survival Data in Patients with High-Risk Uterine Sarcoma

Zaher Alwafai  1 , Verena M C Reichert  1 , Paula Spring  1 , Marek Zygmunt  1 , Günter Köhler  1
Affiliations

Results of Endometrial Biopsy and Its Impact on Survival Data in Patients with High-Risk Uterine Sarcoma

Zaher Alwafai et al. J Clin Med. .

Abstract

Background: There are conflicting data regarding the detection rate of high-risk uterine sarcoma (HRUS) by endometrial biopsy. In addition, there are no studies in the literature on its impact on the chosen surgical approach and survival. Methods: This study includes 415 patients with HRUS. Of these, 178 (42.9%) patients had undergone endometrial biopsy. We analyzed the detection rate of endometrial biopsy and its impact on surgical approach and survival data. Results: Correct specific histologic diagnosis was achieved in only 30.0% of LMS and 33.3% of HGESS/UUS. Other uterine sarcoma, unspecified malignant mesenchymal tumor, carcinosarcoma or carcinoma were found in 45% of LMS and 78.2% of HGESS/UUS. As a result of the histologic findings, the rate of inadequate surgery was reduced by up to 19.9%. As tumor morcellation was performed significantly less often with biopsy (32.5% with vs. 55.4% without biopsy, p < 0.001), the locoregional recurrence-free interval remained unaffected between the two groups (p = 0.81). This is obviously an advantage of biopsy, although it does not affect the local recurrence rate in morcellated patients. Conclusions: Indicated endometrial biopsy is an important step in the diagnosis of HRUS, despite its low detection rate. It helps to avoid inappropriate surgical procedures but does not affect OS.

Keywords: endometrial biopsy; endometrial curettage; histological findings; survival; uterine sarcoma.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Impact of endometrial biopsy on OS in LMS and HGESS/USS.
Figure 2
Figure 2
Impact of endometrial biopsy on locoregional relapse-free interval in LMS and HGESS/USS.
Figure 3
Figure 3
Impact of endometrial biopsy on distant relapse-free interval in LMS and HGESS/USS.
See this image and copyright information in PMC

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