Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1985 Dec;318(6046):533-8.
doi: 10.1038/318533a0.

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

J M Adams, A W Harris, C A Pinkert, L M Corcoran, W S Alexander, S Cory, R D Palmiter, R L Brinster

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

J M Adams et al. Nature. 1985 Dec.

Abstract

Transgenic mice bearing the cellular myc oncogene coupled to the immunoglobulin mu or kappa enhancer frequently develop a fatal lymphoma within a few months of birth. Since the tumours represent represent both immature and mature B lymphocytes, constitutive c-myc expression appears to be highly leukaemogenic at several stages of B-cell maturation. These myc mice should aid study of lymphoma development, B-cell ontogeny and immunoglobulin regulation.

PubMed Disclaimer

Publication types