Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jun 30;60(7):1078.
doi: 10.3390/medicina60071078.

Tricuspid Annular Plane Systolic Excursion-to-Systolic Pulmonary Artery Pressure Ratio as a Prognostic Factor in Heart Transplant Patients

Laurentiu Huma  1   2   3 , Horatiu Suciu  1   4 , Calin Avram  5 , Radu-Adrian Suteu  1 , Alina Danilesco  6 , Dragos-Florin Baba  1   2 , Diana-Andreea Moldovan  1   3   7 , Anca-Ileana Sin  2
Affiliations

Tricuspid Annular Plane Systolic Excursion-to-Systolic Pulmonary Artery Pressure Ratio as a Prognostic Factor in Heart Transplant Patients

Laurentiu Huma et al. Medicina (Kaunas). .

Abstract

Background and Objectives: Heart transplant is currently the final step in treating patients with heart failure. The success of this procedure is strongly connected to potential complications such as postoperative heart failure, infections, graft rejection, graft vasculopathy, and kidney failure. Thus, identifying potential prognostic factors for patients' outcome is of utmost importance. We investigated the prognostic role of the postoperative ratio between the tricuspid annular plane systolic excursion (TAPSE) and systolic pulmonary artery pressure (sPAP) in patients who underwent heart transplantation in our center. Materials and Methods: The study included 46 adult patients from the Emergency Institute for Cardiovascular Diseases and Transplant of Târgu Mureș, who underwent heart transplant between January 2011 and April 2023. By the use of receiver operating characteristic (ROC) analysis, we determined an optimal cut-off value for TAPSE/sPAP with regard to survival at 6 months. Differences in central tendencies of baseline characteristics in those who had a value lower than the cut-off value of TAPSE/sPAP and those who presented a value above it were investigated using the corresponding parametric or nonparametric tests. Results: A value for TAPSE/sPAP above 0.47 mm/mmHg was associated with 6-month survival (OR: 59.5, CI: 5.7-616.0). No significant differences in central tendencies for baseline characteristics were found between the patients who had a TAPSE/sPAP ratio below the cut-off and those who had a ratio above it. Conclusions: The TAPSE/sPAP ratio might prove to be valuable in the early identification of at-risk heart transplant patients. Further prospective studies with larger cohorts are required for validation.

Keywords: TAPSE/sPAP; complications; heart transplant; mortality; survival.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Inclusion criteria of our study. BMI: body mass index; BSA: body surface area; ICU: intensive care unit.
Figure 2
Figure 2
Stage two of the study—comparing central tendencies. ROC: receiver operating characteristic; TAPSE: tricuspid annular plane systolic excursion; sPAP: systolic pulmonary artery pressure. BMI: body mass index; BSA: body surface area; ICU: intensive care unit.
Figure 3
Figure 3
Predictive value of TAPSE/sPAP ratio for 6-month survival. TAPSE: tricuspid annular plane systolic excursion; sPAP: systolic pulmonary artery pressure.
See this image and copyright information in PMC

References

    1. Brink J.G., Hassoulas J. The first human heart transplant and further advances in cardiac transplantation at Groote Schuur Hospital and the University of Cape Town—With reference to: The operation. A human cardiac transplant: An interim report of a successful operation performed at Groote Schuur Hospital, Cape Town. Cardiovasc. J. Afr. 2009;20:31–35. - PMC - PubMed
    1. Alraies M.C., Eckman P. Adult heart transplant: Indications and outcomes. J. Thorac. Dis. 2014;6:1120–1128. doi: 10.3978/J.ISSN.2072-1439.2014.06.44. - DOI - PMC - PubMed
    1. Goda A., Williams P., Mancini D., Lund L.H. Selecting patients for heart transplantation: Comparison of the Heart Failure Survival Score (HFSS) and the Seattle Heart Failure Model (SHFM) J. Heart Lung Transplant. 2011;30:1236–1243. doi: 10.1016/j.healun.2011.05.012. - DOI - PubMed
    1. Awad M.A., Shah A., Griffith B.P. Current status and outcomes in heart transplantation: A narrative review. Rev. Cardiovasc. Med. 2022;23:11. doi: 10.31083/j.rcm2301011. - DOI - PubMed
    1. Baba D.-F., Suciu H., Avram C., Gyorgy M., Danilesco A., Huma L., Sin I.A. Elevated Levels of Neutrophil-to Monocyte Ratio Are Associated with the Initiation of Paroxysmal Documented Atrial Fibrillation in the First Two Months after Heart Transplantation: A Uni-Institutional Retrospective Study. J. Cardiovasc. Dev. Dis. 2023;10:81. doi: 10.3390/jcdd10020081. - DOI - PMC - PubMed

LinkOut - more resources