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. 2024 Jul 10;60(7):1118.
doi: 10.3390/medicina60071118.

Leptin, Ghrelin, Irisin, Asprosin and Subfatin Changes in Obese Women: Effect of Exercise and Different Nutrition Types

Elif Bengin  1 , Abdurrahman Kırtepe  2 , Vedat Çınar  2 , Taner Akbulut  3 , Luca Russo  4 , İsa Aydemir  5 , Polat Yücedal  6 , Süleyman Aydın  7 , Gian Mario Migliaccio  8
Affiliations

Leptin, Ghrelin, Irisin, Asprosin and Subfatin Changes in Obese Women: Effect of Exercise and Different Nutrition Types

Elif Bengin et al. Medicina (Kaunas). .

Abstract

Background and Objectives: In this study, the effects of a six-week training program and various diets on subfatin, asprosin, irisin, leptin, ghrelin and the lipid profile were investigated in overweight women. Materials and Methods: A total of 78 women voluntarily participated in the study. Groups: The study was divided into eight groups: Healthy Control, Obese Control, Obese + Vegetarian, Obese + Ketogenic, Obese + Intermittent Fasting, Obese + Exercise + Vegetarian, Obese + Exercise + Ketogenic and Obese + Exercise + Intermittent Fasting. While there was no intervention in the healthy and obese control groups, the other groups followed predetermined exercise and diet programs for 6 weeks. Blood samples were taken from the participants in the research group twice (before and after the interventions). An autoanalyzer was used to determine the lipid profile in the blood samples taken, and the ELISA method was used to analyze other parameters. Results: Overall, a significant difference was found in the values of weight, BMI, subfatin, ghrelin, leptin, cholesterol, triglyceride, HDL and LDL as a result of the exercise and diet interventions (p < 0.05). There was no significant difference in asprosin and irisin values (p > 0.05). Conclusions: In conclusion, regular exercise and dietary interventions in obese women can regulate lipid profile, ghrelin, leptin and asprosin levels, and increasing irisin with exercise can activate lipid metabolism and support positive changes in lean mass.

Keywords: asprosin; diet; exercise; nutrition; ırisin.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Research design.
Figure 2
Figure 2
Body weight (A) and BMI (B) levels. Healthy Control (HC), Obese Control (OC), Obese + Vegetarian (O + V), Obese + Ketogenic (O + K), Obese + Intermittent Fasting (O + IF), Obese + Vegetarian + Exercise (O + V + E), Obese + Ketogenic + Exercise (O + K + E) and Obese + Intermittent Fasting+ Exercise (O + IF + E). * p < 0.05, NS; non-significant and ES; Effect Size.
Figure 3
Figure 3
Cholesterol (A), Triygliceride (B), HDL-Cholesterol (C) and LDL-Cholesterol (D) levels. Healthy Control (HC), Obese Control (OC), Obese + Vegetarian (O + V), Obese + Ketogenic (O + K), Obese + Intermittent Fasting (O + IF), Obese + Vegetarian + Exercise (O + V + E), Obese + Ketogenic + Exercise (O + K + E) and Obese + Intermittent Fasting+ Exercise (O + IF + E). * p < 0.05, NS; non-significant and ES; Effect Size.
Figure 4
Figure 4
Leptin (A) and ghrelin (B) levels. Healthy Control (HC), Obese Control (OC), Obese + Vegetarian (O + V), Obese + Ketogenic (O + K), Obese + Intermittent Fasting (O + IF), Obese + Vegetarian + Exercise (O + V + E), Obese + Ketogenic + Exercise (O + K + E) and Obese + Intermittent Fasting+ Exercise (O + IF + E). *; p < 0.05, NS; non-significant and ES; Effect Size.
Figure 5
Figure 5
Asprosin (A), subfatin (B) and irisin (C) levels. Healthy Control (HC), Obese Control (OC), Obese + Vegetarian (O + V), Obese + Ketogenic (O + K), Obese + Intermittent Fasting (O + IF), Obese + Vegetarian + Exercise (O + V + E), Obese + Ketogenic + Exercise (O + K + E) and Obese + Intermittent Fasting+ Exercise (O + IF + E). *; p < 0.05, NS; non-significant and ES; Effect Size.
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