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. 2024 Jul 12;16(14):2239.
doi: 10.3390/nu16142239.

Maternal Circulating Vitamin D Level, Targeted Supplementation, and Perinatal Outcomes in Twin Pregnancy

Sofia Roero  1 , Agata Ingala  1 , Silvana Arduino  1 , Miriam Folino Gallo  1 , Arianna Arese  1 , Isabella Ferrando  1 , Carlotta Bossotti  1 , Alberto Revelli  1
Affiliations

Maternal Circulating Vitamin D Level, Targeted Supplementation, and Perinatal Outcomes in Twin Pregnancy

Sofia Roero et al. Nutrients. .

Abstract

Background: Vitamin D deficiency is associated with several obstetric complications in singleton pregnancy. The aim of this study was to assess whether vitamin D levels affect the outcomes of twin pregnancy and if targeted supplementation can improve perinatal outcomes.

Methods: The serum vitamin D levels of 143 women with twin pregnancies were measured during their first trimester. Those with insufficient (10-30 ng/mL; IL group) or severely deficient (<10 ng/mL, DL group) vitamin D levels were supplemented. In the third trimester, vitamin D levels were reassessed. Perinatal outcomes of the IL and DL groups were compared with those of patients with sufficient levels (>30 ng/mL, SL group) since the beginning of pregnancy.

Results: Women in the IL and DL groups had a higher incidence of hypertensive disorders of pregnancy (HDP) compared to the SL group (24.8% and 27.8% vs. 12.5%, p = 0.045): OR = 1.58 for the IL group and 1.94 for the DL group compared to the SL group. In patients whose vitamin D levels were restored after supplementation, HDP incidence was lower than in patients who remained in the IL or DL groups (23.4% vs. 27.3%) but higher than those who were always in the SL group (12.5%).

Conclusions: Insufficient or severely deficient levels of vitamin D in the first trimester are associated with an increased risk of HDP in twin pregnancy. The beneficial effect of targeted vitamin D supplementation in reducing HDP seems limited.

Keywords: hypertensive disorders of pregnancy; perinatal outcome; twin pregnancy; vitamin D.

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Conflict of interest statement

The authors declare no conflicts of interest.

References

    1. Witteveen T., Van Den Akker T., Zwart J.J., Bloemenkamp K.W., Van Roosmalen J. Severe acute maternal morbidity in multiple pregnancies: A nationwide cohort study. Am. J. Obstet. Gynecol. 2016;214:641.e1–641.e10. doi: 10.1016/j.ajog.2015.11.003. - DOI - PubMed
    1. Khalil A., Rodgers M., Baschat A., Bhide A., Gratacos E., Hecher K., Kilby M.D., Lewi L., Nicolaides K.H., Oepkes D., et al. ISUOG Practice Guidelines: Role of ultrasound in twin pregnancy. Ultrasound Obstet. Gynecol. 2016;47:247–263. doi: 10.1002/uog.15821. - DOI - PubMed
    1. American College of Obstetricians and Gynecologists’ Committee on Practice Bulletins—Obstetrics, Society for Maternal-Fetal Medicine Practice Bulletin No. 169: Multifetal Gestations: Twin, Triplet, and Higher-Order Multifetal Pregnancies. Obstet. Gynecol. 2016;128:e131–e146. doi: 10.1097/AOG.0000000000001709. - DOI - PubMed
    1. NICE NICE Guideline: Twin and Triplet Pregnancy. 2019. [(accessed on 14 June 2024)]. Available online: www.nice.org.uk/guidance/ng137.
    1. Goodnight W., Newman R. Optimal nutrition for improved twin pregnancy outcome. Obstet. Gynecol. 2009;114:1121–1134. doi: 10.1097/AOG.0b013e3181bb14c8. - DOI - PubMed

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