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. 1979 Aug;86(2):321-4.
doi: 10.1093/oxfordjournals.jbchem.a132529.

Magnesium-sensitive guanylate cyclase and its endogenous activating factor in Tetrahymena pyriformis

K Nakazawa, H Shimonaka, S Nagao, S Kudo, Y Nozawa
Free article

Magnesium-sensitive guanylate cyclase and its endogenous activating factor in Tetrahymena pyriformis

K Nakazawa et al. J Biochem. 1979 Aug.
Free article

Abstract

Guanylate cyclase [EC 4.6.1.2] activity in Tetrahymena pyriformis cells was associated with particulate fractions, but not with soluble fractions. Mg2+ was much more effective than Mn2+ in activating the cyclase activity. Both specific and total cyclase activities with Mg2+ in the particulate fraction were very much lower than those in the original homogenate. The addition of the soluble fraction resulted in a marked enhancement of the particulate-bound cyclase activity, while the adenylate cyclase [EC 4.6.1.1] activity was not enhanced. The enhancement was dependent on Ca2+, and the activating factor is suggested to be a protein.

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