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Review
. 2024 Aug;45(8):565-567.
doi: 10.1016/j.it.2024.07.003. Epub 2024 Jul 26.

Mutant ARID1A: igniting cancer immunotherapy

Bujamin H Vokshi  1 , Eneda Toska  2
Affiliations
Review

Mutant ARID1A: igniting cancer immunotherapy

Bujamin H Vokshi et al. Trends Immunol. 2024 Aug.

Abstract

Maxwell et al. show that ARID1A loss enhances antitumor immunity by triggering a type I IFN response through the cGAS-STING pathway, thereby promoting T cell infiltration and cytotoxicity. These findings highlight SWI/SNF inhibitors as a strategy to augment immunotherapy efficacy by potentially transforming non-responsive tumors into responders and advancing approaches to cancer treatment.

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Conflict of interest statement

Declaration of interests E.T reports grants from AstraZeneca and consulting fees from Menarini. B.H.K. declares no competing interests.

References

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