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. 2024 Jul 1;25(7):2311-2317.
doi: 10.31557/APJCP.2024.25.7.2311.

Type I or Type II Endometrial Carcinoma? Role of BRCA1 Immunohistochemistry

Sara Ahmed Ali Eldegwi  1 , Maha Mohamed Amin  1 , Sylvia Albair Ashamalla  1 , Reham Alghandour  2 , Reham Mohamed Nagib  1
Affiliations

Type I or Type II Endometrial Carcinoma? Role of BRCA1 Immunohistochemistry

Sara Ahmed Ali Eldegwi et al. Asian Pac J Cancer Prev. .

Abstract

Objectives: Investigation of diagnostic and prognostic relevance of BRCA1 immunohistochemistry (IHC) in endometrial carcinoma.

Methods: Ninty four specimens of endometrial carcinomas were evaluated. Full sections stained with hematoxylin & eosin were revaluated for assessment of tumor type, grade, myometrial, & lympho-vascular invasion (LVI). Tissue microarray blocks were constructed using the pencil tip method and immunostained with Anti-BRCA1 antibody. BRCA1 was correlated with clinicopathological parameters as well as disease free survival and overall survival.

Results: There was a statistically significant difference (P=0.001) between serous and endometroid carcinomas regarding BRCA1 expression where most cases of serous carcinoma showed negative expression. No statistically significant difference was found between BRCA1 positive and negative cases regarding disease free survival (DFS) or overall survival. Serous histotype, high grade, advanced stage, and omental deposits were the parameters significantly associated with decreased DFS.

Conclusion: Results of this study can support inclusion of BRCA1 IHC in a panel to differentiate both endometroid and serous carcinomas. The current study found no prognostic relevance for BRCA1 in terms of overall survival and disease-free survival.

Keywords: BRCA1; Endometroid; serous.

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Figures

Figure 1
Figure 1
A Case of GI Endometrioid Carcinoma. (A) Predominantly glandular structures more than 50% of the tumor with tumor cells showing mild atypia (H&E X400). (B) Positive nuclear& cytoplasmic BRCA1 expression (IHC for BRCA1 X400).
Figure 2
Figure 2
A Case of Serous Carcinoma. (A): Papillae and glandular structures with intra-luminal tufting .Tumor cells showing high degree of atypia and pleomorphism (H&E X400). (B): Negative nuclear BRCA1 expression (IHC for BRCA1 X400)
See this image and copyright information in PMC

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