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Review
. 2024 Sep 1;327(3):C607-C613.
doi: 10.1152/ajpcell.00405.2024. Epub 2024 Jul 29.

The utility-and limitations-of the rodent synergist ablation model in examining mechanisms of skeletal muscle hypertrophy

Michael D Roberts  1 , Troy A Hornberger  2 , Stuart M Phillips  3
Affiliations
Review

The utility-and limitations-of the rodent synergist ablation model in examining mechanisms of skeletal muscle hypertrophy

Michael D Roberts et al. Am J Physiol Cell Physiol. .

Abstract

In this issue, Burke et al. discuss the utility of the rodent synergist ablation (SA) model for examining mechanisms associated with skeletal muscle hypertrophy. In this invited perspective, we aim to complement their original perspective by discussing limitations to the model along with alternative mechanical overload models that have strengths and limitations.

Keywords: skeletal muscle; synergist ablation.

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Conflict of interest statement

The laboratory of M.D.R. performs industry- and commodity-based contract work, with recent support being received by the US National Dairy Council, The US Peanut Institute, The Center for Applied Health Sciences, MegaFood, and a three-year laboratory donation from Nutrabolt. MDR also performs consulting for personal fees with industry partners in accordance with Auburn University’s faculty consulting and annual disclosure policies. T.A.H. has no conflicts of interest to report. S.M.P. receives personal fees from US National Dairy Council, non-financial support from Enhanced Recovery, and has a patent (Canadian) 3052324 assigned to Exerkine and a patent (US) 20200230197 pending to Exerkine but reports no financial gains from any patent or related work.

Figures

Figure 1.
Figure 1.
Estimated growth curves of humans and mice. These data were redrawn by M.D.R. from data provided through the Jackson Laboratory (jax.org) and (50). Note males and females from each species are averaged here, and the blue box highlights rapid growth similarities in both species.
See this image and copyright information in PMC

References

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    1. Roberts MD, McCarthy JJ, Hornberger TA, Phillips SM, Mackey AL, Nader GA, Boppart MD, Kavazis AN, Reidy PT, Ogasawara R, Libardi CA, Ugrinowitsch C, Booth FW, Esser KA. Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions. Physiol Rev 103: 2679–2757, 2023. doi: 10.1152/physrev.00039.2022. - DOI - PMC - PubMed
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