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. 2024 Jul 25;19(1):20241002.
doi: 10.1515/med-2024-1002. eCollection 2024.

Comparison of the ability of newly inflammatory markers to predict complicated appendicitis

Ali Saridas  1 , Nafis Vural  2 , Murat Duyan  3 , Hasan Can Guven  3 , Elif Ertas  4 , Basar Cander  5
Affiliations

Comparison of the ability of newly inflammatory markers to predict complicated appendicitis

Ali Saridas et al. Open Med (Wars). .

Abstract

Introduction: Acute appendicitis (AA) is the predominant condition responsible for acute abdominal pain across all age demographics. The purpose of this research is to determine if the hemoglobin, albumin, lymphocyte, and platelet (HALP) and modified HALP (m-HALP) scores differ between complicated and uncomplicated appendicitis in patients diagnosed with AA who have applied to the emergency department (ED). Additionally, this study aims to investigate whether HALP and m-HALP scores are superior to other biomarkers.

Materials and methods: The retrospective analysis included adult patients, aged eighteen or older, who were diagnosed with AA, and sought treatment at the ED of a tertiary hospital. Patients were divided into two groups: complicated appendicitis (CA) and uncomplicated appendicitis (UCA). The cut-off in diagnostic value measurements was determined using the receiver operating characteristic analysis.

Results: A total of 436 patients (CA: 126, UCA: 310) were included. Neutrophil-to-lymphocyte ratio (NLR), neutrophil-to-albumin ratio, systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and pan-immune inflammation value (PIV) were found to have acceptable diagnostic power in CA detection (area under the curve [AUC]: 0.735-0.783). In detecting UCA, HALP and m-HALP were of fair diagnostic power (AUC: 0.64, 0.68, respectively).

Conclusions: In this study, we found that although PIV, SIRI, SII, and NLR had acceptable diagnostic values in distinguishing CA and UCA, HALP and m-HALP had fair diagnostic values.

Keywords: HALP; acute appendicitis; complicated appendicitis; emergency department; m-HALP.

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Conflict of interest statement

Conflict of interest: The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
The ROC curves of biomarkers for predicting complicated acute appendicitis. NLR: neutrophil-to-lymphocyte ratio, NAR: neutrophil-to-albumin ratio, NPR: neutrophil-to-platelet ratio, SII: systemic immune inflammation index, SIRI: systemic inflammation response index, PIV: pan-immune inflammation value.
Figure 2
Figure 2
The ROC curves of biomarkers for predicting uncomplicated acute appendicitis. HALP: hemoglobin × albumin levels × lymphocyte count/platelet count, m-HALP: modified HALP.
See this image and copyright information in PMC

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