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Review
. 2021 Dec 31:2021:6584693.
doi: 10.1155/2021/6584693. eCollection 2021.

Phytochemical Constituents, Biological Activities, and Health-Promoting Effects of the Melissa officinalis

Javad Sharifi-Rad  1 , Cristina Quispe  2 , Jesús Herrera-Bravo  3   4 , Muhammad Akram  5 , Wafa Abbaass  5 , Prabhakar Semwal  6   7 , Sakshi Painuli  6   8 , Dmitry Alekseevich Konovalov  9 , Mary Angelia Alfred  10 , Nanjangud Venkatesh Anil Kumar  10 , Muhammad Imran  11 , Muhammad Nadeem  12 , Barbara Sawicka  13 , Piotr Pszczółkowski  14 , Bernadetta Bienia  15 , Piotr Barbaś  16 , Shafi Mahmud  17 , Alessandra Durazzo  18 , Massimo Lucarini  18 , Antonello Santini  19 , Miquel Martorell  20   21 , Daniela Calina  22
Affiliations
Review

Phytochemical Constituents, Biological Activities, and Health-Promoting Effects of the Melissa officinalis

Javad Sharifi-Rad et al. Oxid Med Cell Longev. .

Retraction in

Abstract

Medicinal plants are being used worldwide for centuries for their beneficial properties. Some of the most popular medicinal plants belong to the Melissa genus, and different health beneficial effects have already been identified for this genus. Among these species, in particular, the Melissa officinalis L. has been reported as having many biological activities, such as antioxidant, antimicrobial, antitumour, antiviral, antiallergic, anti-inflammatory, and also flatulence inhibiting effects. The beneficial properties of the Melissa officinalis, also known as "lemon balm herb", can be related to the bioactive compounds such as terpenoids, alcohols, rosmarinic acid, and phenolic antioxidants which are present in the plant. In this updated review, the botanical, geographical, nutritional, phytochemical, and traditional medical aspects of M. officinalis have been considered as well as in vitro and in vivo and clinically proven therapeutic properties have been reviewed with a special focus on health-promoting effects and possible perspective nutraceutical applications. To evidence the relevance of this plant in the research and completely assess the context, a literature quantitative research analysis has been performed indicating the great interest towards this plant for its beneficial properties.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Publication and citations trends of Melissa officinalis and health research (bibliometric data were extracted from the Scopus online database).
Figure 2
Figure 2
Distribution of type document (bibliometric data were extracted from the Scopus online database).
Figure 3
Figure 3
Most productive authors (bibliometric data were extracted from the Scopus online database).
Figure 4
Figure 4
Most productive countries/territories (based on data from Scopus).
Figure 5
Figure 5
Term map for relationships of Melissa officinalis and health research. The number of publications was represented by bubble size. The citations per publication (CPP) was given by bubble colour. Two bubbles are closer to each other reflecting that the terms coappeared more frequently (bibliometric data were extracted from the Scopus online database and elaborated by VOSviewer software).
Figure 6
Figure 6
Summarized scheme with the most important bioactive compounds from M officinalis and their correlation with biological activities.
See this image and copyright information in PMC

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