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Editorial
. 2024 Jul 24;15(7):786-789.
doi: 10.5306/wjco.v15.i7.786.

Anaplastic thyroid cancer: Unveiling advances in diagnosis and management

Affiliations
Editorial

Anaplastic thyroid cancer: Unveiling advances in diagnosis and management

Treshita Dey et al. World J Clin Oncol. .

Abstract

The review article by Pavlidis et al published in World J Clin Oncol provides a meticulous analysis of the intricacies surrounding anaplastic carcinoma of the thyroid. Thyroid carcinoma encompasses a spectrum of diseases, each characterized by distinct behaviors and outcomes. Diagnostic approaches encompass a diverse array of tools. Surgery remains the pivotal treatment for anaplastic thyroid carcinoma. Radiotherapy and chemotherapy offer the best overall survival in aggressive disease. Combinations of immunotherapy with targeted therapies, such as dabrafenib-trametinib, demonstrate potential for enhanced effectiveness and improved survival outcomes. Multifaceted approach fuelled by precision medicine and interdisciplinary collaboration is imperative in charting a course toward improved outcomes in this formidable malignancy.

Keywords: Anaplastic thyroid cancer; Chemotherapy; Immunotherapy; Radiotherapy; Surgery; Targeted therapy.

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Conflict of interest statement

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

References

    1. Pavlidis ET, Galanis IN, Pavlidis TE. Update on current diagnosis and management of anaplastic thyroid carcinoma. World J Clin Oncol. 2023;14:570–583. - PMC - PubMed
    1. Yadav BS, Sharma SC. Breast and Thyroid Cancer Association. Int J Radiat Oncol Biol Phys. 2009;73:1604.
    1. Maniakas A, Dadu R, Busaidy NL, Wang JR, Ferrarotto R, Lu C, Williams MD, Gunn GB, Hofmann MC, Cote G, Sperling J, Gross ND, Sturgis EM, Goepfert RP, Lai SY, Cabanillas ME, Zafereo M. Evaluation of Overall Survival in Patients With Anaplastic Thyroid Carcinoma, 2000-2019. JAMA Oncol. 2020;6:1397–1404. - PMC - PubMed
    1. Chiofalo MG, Signoriello S, Fulciniti F, Avenia N, Ristagno S, Lombardi CP, Nicolosi A, Pelizzo MR, Perigli G, Polistena A, Panebianco V, Bellantone R, Calò PG, Boschin IM, Badii B, Di Maio M, Gallo C, Perrone F, Pezzullo L. Predictivity of clinical, laboratory and imaging findings in diagnostic definition of palpable thyroid nodules. A multicenter prospective study. Endocrine. 2018;61:43–50. - PMC - PubMed
    1. Zhu Y, Song Y, Xu G, Fan Z, Ren W. Causes of misdiagnoses by thyroid fine-needle aspiration cytology (FNAC): our experience and a systematic review. Diagn Pathol. 2020;15:1. - PMC - PubMed

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