Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
[Preprint]. 2024 Jul 18:2024.07.16.24310413.
doi: 10.1101/2024.07.16.24310413.

2023-24 dengue outbreak in Valle del Cauca, Colombia caused by multiple virus serotypes and lineages

Nathan D Grubaugh  1   2   3   4 , Daniela Torres-Hernández  5 , Mónica A Murillo-Ortiz  6   7 , Diana M Dávalos  8 , Pio Lopez  8 , Isabel C Hurtado  5   7   9 , Mallery I Breban  1 , Ellie Bourgikos  1 , Verity Hill  1 , Eduardo López-Medina  5   8   10
Affiliations

2023-24 dengue outbreak in Valle del Cauca, Colombia caused by multiple virus serotypes and lineages

Nathan D Grubaugh et al. medRxiv. .

Update in

Abstract

Global dengue cases rapidly rose to record levels in 2023-24. We investigated this trend in Valle del Cauca, Colombia to determine if specific dengue virus serotypes or lineages were responsible for the large outbreak. We detected all four serotypes and multiple lineages, suggesting that other factors, such as climatic conditions, are likely responsible.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.. Dengue cases by virus serotype and lineage in Valle del Cauca, Colombia.
(A) Monthly dengue cases reported by Valle del Cauca State Health Department in Colombia. Samples from confirmed dengue cases (n=266) sorted by DENV (A) serotype per month by RT-qPCR (unknown = below limits of PCR detection) and (B) lineage by amplicon-based sequencing (listed as serotype, genotype, and lineage).
Figure 2.
Figure 2.. Time-resolved maximum-likelihood phylogeny of DENV-1.
(A) Full reconstruction of 1007 DENV-1 sequences colored by sampling location. (B) Zoom on the DENV-1V_D clade highlighting sequences from Cali, Colombia (black).
Figure 3.
Figure 3.. Time-resolved maximum-likelihood phylogeny of DENV-2.
(A) Full reconstruction of 965 DENV-2 sequences colored by sampling location. Zoom on the (B) DENV-2III_D.2 and (C) DENV-2II_F.1.2 clades highlighting sequences from Cali, Colombia (black).
Figure 4.
Figure 4.. Time-resolved maximum-likelihood phylogeny of DENV-3.
(A) Full reconstruction of 542 DENV-3 sequences colored by sampling location. (B) Zoom on the DENV-3III_C.1 clade highlighting sequences from Cali, Colombia (black).
See this image and copyright information in PMC

References

    1. PAHO/WHO Data - Dengue [Internet]. [cited 2024 Jul 1]. Available from: https://www3.paho.org/data/index.php/en/mnu-topics/indicadores-dengue-en...
    1. Messina JP, Brady OJ, Golding N, Kraemer MUG, Wint GRW, Ray SE, et al. The current and future global distribution and population at risk of dengue. Nature microbiology [Internet]. 2019. Sep [cited 2024 Jun 28];4(9). Available from: https://pubmed.ncbi.nlm.nih.gov/31182801/ - PMC - PubMed
    1. Chen Y, Xu Y, Wang L, Liang Y, Li N, Lourenço J, et al. Indian Ocean temperature anomalies predict long-term global dengue trends. Science [Internet]. 2024. May 10 [cited 2024 Jul 1]; Available from: 10.1126/science.adj4427 - DOI - PubMed
    1. Cerpas C, Vásquez G, Moreira H, Juarez JG, Coloma J, Harris E, et al. Introduction of New Dengue Virus Lineages of Multiple Serotypes after COVID-19 Pandemic, Nicaragua, 2022 - Volume 30, Number 6—June 2024 - Emerging Infectious Diseases journal - CDC. [cited 2024 Jul 1]; Available from: https://wwwnc.cdc.gov/eid/article/30/6/pdfs/23-1553.pdf - PMC - PubMed
    1. Taylor-Salmon E, Hill V, Paul LM, Koch RT, Breban MI, Chaguza C, et al. Travel surveillance uncovers dengue virus dynamics and introductions in the Caribbean. Nat Commun. 2024. Apr 25;15(1):1–14. - PMC - PubMed

Publication types

LinkOut - more resources