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Review
. 2024 Jul 30;150(5):347-349.
doi: 10.1161/CIRCULATIONAHA.124.070136. Epub 2024 Jul 29.

Myocardial Regeneration: Feasible or Fantasy?

Affiliations
Review

Myocardial Regeneration: Feasible or Fantasy?

Eric N Olson. Circulation. .
No abstract available

Keywords: genetic therapy; heart diseases; regeneration.

PubMed Disclaimer

Conflict of interest statement

Dr Olson is a consultant for Cardurion, Dynomics, Prime Medicine, ReCode, The Column Group, Tenaya, and Vertex.

Figures

Figure.
Figure.
Biologic processes and potential therapies for regeneration of the adult heart.

References

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    1. Sadek H, Olson EN. Toward the goal of human heart regeneration. Cell Stem Cell. 2020;26:7–16. doi: 10.1016/j.stem.2019.12.004 - DOI - PMC - PubMed
    1. Li X, Wu F, Günther S, Looso M, Kuenne C, Zhang T, Wiesnet M, Klatt S, Zukunft S, Fleming I, et al. Inhibition of fatty acid oxidation enables heart regeneration in adult mice. Nature. 2023;622:619–626. doi: 10.1038/s41586-023-06585-5 - DOI - PMC - PubMed
    1. Aghajanian H, Rurik JG, Epstein JA. CAR-based therapies: opportunities for immuno-medicine beyond cancer. Nat Metab. 2022;4:163–169. doi: 10.1038/s42255-022-00537-5 - DOI - PMC - PubMed
    1. Liu N, Olson EN. CRISPR modeling and correction of cardiovascular disease. Circ Res. 2022;130:1827–1850. doi: 10.1161/CIRCRESAHA.122.320496 - DOI - PMC - PubMed

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