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Observational Study
. 2024 Jul 29;24(1):260.
doi: 10.1186/s12871-024-02651-1.

Opioid free analgesia after return home in ambulatory colonic surgery patients: a single-center observational study

Marilyn Gosgnach  1   2 , Philippe Chasserant  3   4 , Mathieu Raux  5   6
Affiliations
Observational Study

Opioid free analgesia after return home in ambulatory colonic surgery patients: a single-center observational study

Marilyn Gosgnach et al. BMC Anesthesiol. .

Abstract

Background: Because of the adverse effects of morphine and its derivatives, non-opioid analgesia procedures are proposed after outpatient surgery. Without opioids, the ability to provide quality analgesia after the patient returns home may be questioned. We examined whether an opioid-free strategy could ensure satisfactory analgesia after ambulatory laparoscopic colectomy.

Methods: We performed a retrospective observational single-center study (of prospective collected database) including all patients eligible for scheduled outpatient colectomy. Postoperative analgesia was provided by paracetamol and nefopam. Postoperative follow-up included pain at mobilization (assessed by a numerical rating scale, NRS), hemodynamic variables, temperature, resumption of transit and biological markers of postoperative inflammation. The primary outcome was the proportion of patients with moderate to severe pain (NRS > 4) the day after surgery.

Results: Data from 144 patients were analyzed. The majority were men aged 59 ± 12 years with a mean BMI of 27 [25-30] kg/m2. ASA scores were 1 for 14%, 2 for 59% and 3 for 27% of patients. Forty-seven patients (33%) underwent surgery for cancer, 94 for sigmoiditis (65%) and 3 (2%) for another colonic pathology. Postoperative pain was affected by time since surgery (Q3 = 52.4,p < 0.001) and decreased significantly from day to day. The incidence of moderate to severe pain at mobilization (NRS > 4) on the first day after surgery was (0.19; 95% CI, 0.13-0.27).

Conclusion: Non-opioid analgesia after ambulatory laparoscopic colectomy seems efficient to ensure adequate analgesia. This therapeutic strategy makes it possible to avoid the adverse effects of opioids.

Trial registration: The study was retrospectively registered and approved by the relevant institutional review board (CERAR) reference IRB 00010254-2018 - 188). All patients gave written informed consent for analysis of their data. The anonymous database was declared to the French Data Protection Authority (CNIL) (reference 221 2976 v0 of April 12, 2019).

Keywords: Ambulatory surgery; Colectomy; Laparoscopic surgery; Opioid-free analgesia; Postoperative pain.

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Conflict of interest statement

Competing interests. The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flow chart of patients in the study
Fig. 2
Fig. 2
Pain intensity at mobilization, assessed by a simple numerical rating scale (NRS) at postoperative day 1 (POD1), POD 2 and POD 3 after ambulatory laparoscopic colectomy. * stands for p < 0.05 and *** stands for p < 0.001
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